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  • 2000-2004  (2)
  • HNF-4γ  (1)
  • PACS. 03.65.Ud Entanglement and quantum nonlocality (e.g. EPR paradox, Bell's inequalities, GHZ states, etc.) – 03.67.Lx Quantum computation – 75.10.Jm Quantized spin models  (1)
  • 1
    Digitale Medien
    Digitale Medien
    No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4γ gene (HNF4G) in Japanese patients with MODY (2000)
    Springer
    Diabetologia 43 (2000), S. 1064-1069 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Keywords Maturity-onset diabetes of the young ; MODY ; transcription factor ; nuclear receptor ; HNF-4γ ; diabetes mellitus ; insulin ; genetics ; mutation.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Aims/hypothesis. Mutations in the transcription factor hepatocyte nuclear factor (HNF)-4α are the cause of one form of maturity-onset diabetes of the young, MODY1. The HNF-4γ is structurally related to HNF-4α and is expressed together with HNF-4α in pancreatic islets. We therefore tested the hypothesis that genetic variation in the HNF-4γ gene (HNF4G) is associated with MODY in Japanese subjects. Methods. We screened the protein coding region of HNF4G (exons 3–11) for mutations in 57 unrelated Japanese subjects with MODY by amplifying each exon and adjacent intron region using the polymerase chain reaction (PCR) and specific primers and then directly sequencing the PCR products. The frequency of each variant was compared between patients with MODY and a group of non-diabetic subjects. Results. We found ten sequence variants, two of these were located in exons: exon 6, a silent substitution in codon 144, c.432A/G and exon 7, a G-to-A substitution in codon 190 (c.570G/A) resulting in a conservative Met-to-Ile substitution (M/I190) in the putative ligand-binding region of HNF-4γ protein. The remaining eight variants were located in introns. There was no significant difference in the frequency of these polymorphisms between subjects with MODY and non-diabetic control subjects. Conclusion/interpretation. Genetic variation in the coding region of HNF4G is unlikely to be a major cause of MODY in Japanese people. [Diabetologia (2000) 43: 1064–1069]
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001250051491
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Pairwise entanglement in symmetric multi-qubit systems (2002)
    Springer
    The European physical journal 18 (2002), S. 385-391 
    Details
    ISSN: 1434-6079
    Schlagwort(e): PACS. 03.65.Ud Entanglement and quantum nonlocality (e.g. EPR paradox, Bell's inequalities, GHZ states, etc.) – 03.67.Lx Quantum computation – 75.10.Jm Quantized spin models
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract: For pairs of particles extracted from a symmetric state of N two-level systems, the two-particle density matrix is expressed in terms of expectation values of collective spin operators for the large system. Results are presented for experimentally relevant examples of pure states: Dicke states | S, M〉, spin coherent, and spin squeezed states, where only the symmetric subspace, S = N/2 is populated, and for thermally entangled mixed states populating also lower S values. The entanglement of the extracted pair is then quantified by a calculation of the concurrence, which provides directly the entanglement of formation of the pair.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1140/epjd/e20020045
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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