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  • 1
    Electronic Resource
    Electronic Resource
    BCG induced killer cell activity (1988)
    Springer
    Urological research 16 (1988), S. 351-355 
    Details
    ISSN: 1434-0879
    Keywords: Intravesical BCG ; Peripheral blood mononuclear cells ; Killer activity against natural killer cell (NK) resistant tumors, NK type precursor and effector cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the mechanism of Bacillus de Calmette Guérin (BCG) bladder instillation therapy, the killer cell activity induced in peripheral blood mononuclear cells (PBMNCs) after BCG instillation was examined. Significant cytotoxic activity against natural killer (NK) cell resistant target tumor cells was detected after 3 days of instillation. To characterize this BCG induced cytotoxic activity further, human PBMNCs were cultured with BCG in vitro. From 24 h maximum cytotoxicity was obtained and continued for 3 days, then decreased slightly. Neither a DNA synthesis inhibitor Cytosine-arabinoside (Ara-C) nor a cytotoxic T cell (CTL) generation inhibitor Cyclosporine A inhibited this killer cell activation. Monoclonal antibody treatment revealed that both precursor and effector cells are Leu1-, 3a-, 7+, 11b+. The recognition specificity from cold target competition experiments was selective. Taken together NK type precursor was activated with BCG into NK type effector which has wider spectrum of target cells than usual NK cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256041
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Microneurographic analysis of muscle sympathetic nerve activity in amyotrophic lateral sclerosis (1993)
    Springer
    Clinical autonomic research 3 (1993), S. 131-135 
    Details
    ISSN: 1619-1560
    Keywords: Amyotrophic lateral sclerosis ; Microneurography ; Muscle sympathetic nerve activity ; Blood pressure ; Heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Muscle sympathetic nerve activity by (microneurograph) blood pressure and heart rate has been studied in patients with amyotrophic lateral sclerosis and in age-matched normal subjects (controls) at rest and during head-up tilt. Muscle sympathetic nerve activity in amyotrophic lateral sclerosis patients was significantly increased at rest unlike controls. There was no correlation between muscle sympathetic nerve activity and age in the patients with amyotrophic lateral sclerosis. Elevated muscle sympathetic nerve activity was present mainly in younger patients. There were no differences between blood pressure or heart rate in either group at rest or during head-up tilt in amyotrophic lateral sclerosis. The increase in muscle sympathetic nerve activity following tilt in the amyotrophic lateral sclerosis patients was less than in the controls, but they had no postural hypotension. The possible reasons for this observation of increased muscle sympathetic nerve activity at rest in amyotrophic lateral sclerosis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01818998
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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