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  • Cyanide  (1)
  • Cyprinus carpio  (1)
  • Helicobacter pylori  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Experimental brain research 84 (1991), S. 355-358 
    ISSN: 1432-1106
    Schlagwort(e): Substantia nigra ; Pars compacta neurones ; Cyanide ; KATP channel ; Tolbutamide ; Low threshold calcium conductance ; Parkinson's disease ; Guinea pig
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The ATP-sensitive potassium channel (KATP channel) is a unique ionophore in that it appears to reflect cell metabolism. In the brain, the highest density of binding sites for the KATP channel is the substantia nigra. To evaluate the role of the KATP channel in this key brain area for motor control, we used exposure to cyanide to lower intracellular ATP and thereby mimic anoxia and ischemia. Treatment with cyanide caused the activation of a potassium current in a sub-population of nigral neurones with distinct pharmacological and electrophysiological properties. The response to cyanide was abolished by the sulphonylurea tolbutamide, a potent blocker of the KATP channel. These results suggest that in the substantia nigra, the KATP channel plays a pivotal role in normal mechanisms of neuronal homeostasis in response to anoxia and ischaemia. The significance of these findings for our understanding of the cellular mechanisms in Parkinsonian degeneration is discussed.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Digestive diseases and sciences 39 (1994), S. 1488-1492 
    ISSN: 1573-2568
    Schlagwort(e): Helicobacter pylori ; children ; symptomatology ; gastritis ; ulcers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Helicobacter pylori is an established cause of chronic-active gastritis in both adults and children. However, it is unclear whetherH. pylori causes specific clinical symptoms. Therefore, the spectrum of clinical symptoms associated withH. pylori infection was studied in consecutive symptomatic children undergoing diagnostic endoscopy at two pediatric centers, using a structured questionnaire. In Toronto, Canada, 86 of 97 eligible children were enrolled into the study and in Limerick, Ireland, 24 of 29 were enrolled. The frequency of biopsy-confirmedH. pylori infection in Limerick, 16 of 24 (67%), was fivefold higher than in Toronto, 11 of 86 (13%,P=0.0001). The two study populations were comparable in clinical presentation and duration of symptomatology and did not differ in age (11.9±3.5 and 11.6±2.0 years, respectively). Within both study populationsH. pylori infection was not associated with specific clinical symptomatology, including duration of abdominal pain, location of pain, and history of melena or vomiting.H. pylori was positively associated with hematemesis in the Limerick group. These findings demonstrate thatH. pylori infection in children is not associated with specific clinical symptomatology across varying geographical locations.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1573-5117
    Schlagwort(e): Macrophytes ; irrigation and drainage channels ; turbidity ; Cyprinus carpio ; South America
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract This study examines the relationships between fish, environmental variables and submerged macrophytes within the irrigation system of the lower valley of the Río Colorado in southern Argentina. Using Canonical Correspondence Analysis (CCA), the strongest environmental gradients detected were conductivity and carp ( Cyprinus carpi) biomass per unit area of channel cross-section. These variables were positively associated with each other and also with water turbidity. Sites scoring high on these gradients were mainly drainage channels; those scoring lowest were irrigation channels. The main fish species associated with high carp biomass, high turbidity and high conductivity were carpa ( C. carpio), pejerrey ( Odontesthes bonariensis), madrecita ( Jenynsia lineata lineata) and lisa ( Mugil liza). Dientudo ( Oligosarcus jenynsi) and mojarra ( Astianax eigenmanniorum) were more strongly associated with clearer water, with low carp biomass. In all CCA analyses macrophytes were arranged in similar order along the main conductivity-turbidity-carp biomass gradient. Lowest on this main environmental gradient, and scoring very close to each other, were Potamogeton pectinatus and Chara contraria. Salinity-tolerant species such as Ruppia maritima, Zannichellia palustris and Enteromorpha flexuosa tended to score highest, followed by the surface floating Azolla filiculoides and the filamentous alga Cladophora surera. Within the constraints imposed by conductivity, turbidity was a key predictor of both abundance and distribution of the two dominant plants of the irrigation scheme ( P. pectinatus and C. contraria). Turbidity was strongly predicted by biomass of carp per unit channel cross sectional area, when fine sediment particle content was taken into account. The positive association between carp biomass and water turbidity was both substantial and predictable, and was in turn associated with reduction in submerged plant growth. The biomass of the most widespread nuisance-causing plant species in the channels, Potamogeton pectinatus, could best be predicted ( R = 0.592, P 〈 0.05) using a multiple regression model utilising four predictor variables: conductivity, nitrate, phosphate and carp biomass.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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