ISSN:
1432-1912
Keywords:
Physostigmine
;
Cholinesterase Inhibitors
;
Sympathetic Nervous System
;
Vasomotor System
;
Pralidoxime Compounds
;
Physostigmin
;
Hemmstoffe für die Cholinesterase
;
Sympathisches Nervensystem
;
Vasomotorisches System
;
Pralidoxim-Verbindungen
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In rats in urethane-anaesthesia the intravenous injection of physostigmine 0.5 mg/kg produced a typical rise in blood pressure (hypertensive reaction) which was accompanied by a marked increase in electrical activity in the preganglionic fibres of the cervical sympathetic nerve. Obidoxime and Pralidoxime in doses up to 50 mg/kg i.v. which are both capable to counteract an organophosphate poisoning as antidotes failed to affect the reaction to physostigmine described here. The contradictory results given by the literature are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00536769
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