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  • 1
    Digitale Medien
    Digitale Medien
    Ask the expert (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 138-138 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Hemolytic uremic syndrome ; Immunization ; Vaccination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00862053
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Recent advances in understanding the pathogenesis of the hemolytic uremic syndromes (1990)
    Springer
    Pediatric nephrology 4 (1990), S. 276-283 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Hemolytic uremic syndrome ; Escherichia coli 0157∶H7 ; Shiga-like toxin ; Endothelial cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract One of the requirements for an agent to cause hemolytic uremic syndrome (HUS) is its ability to injure endothelial cells. Shiga-like toxin (SLT) can do this. SLT is produced byEscherichia coli andShigella dysenteriae serotype 1; both have been implicated as causes of typical HUS. Endothelial cells have receptors (GB3) for SLT and the toxin can inhibit eukaryotic protein synthesis, thereby causing cell death. Glomerular endothelial cell injury or death results in a decreased glomerular filtration rate and many of the perturbations seen in HUS. It is no longer certain that hemolysis is the result of a microangiopathy. Cell injury results in release of von Willebrand multimers; if these are ultra-large, thrombosis may ensue. There is also increasing evidence that neutrophils have a role in the pathogenesis of typical HUS.Streptococcus pneumoniae can also cause HUS and care must be taken to avoid giving plasma to patients withS. pneumoniae-associated HUS. There is compelling evidence that types of HUS are inherited by autosomal recessive and autosomal dominant modes. Patients with autosomal recessive HUS may have recurrent episodes. Mortality and morbidity rates are high for the inherited forms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00857676
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura (1995)
    Springer
    Pediatric nephrology 9 (1995), S. 694-699 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Interleukin-6 ; Tumor necrosis factor-α ; Hemolytic uremic syndrome ; Thrombotic thrombocytopenic purpura
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Serum and urine cytokines were analyzed in children with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who developed anuria, extrarenal manifestations during the acute phase of illness and/or chronic renal sequelae. Tumor necrosis factor-α (TNF-α) was detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 and TNF-α were elevated in the urine of 4 of 4 children with HUS and 2 of 2 children with TTP. Urinary levels were higher than serum levels, suggesting local production of cytokines in the urinary tract. Sequential serum and urine samples showed that IL-6 levels varied with disease activity. IL-6 and TNF-α were not detected in the serum (n=25) and urine (n=15) of healthy children. We conclude that IL-6 in urine may be used to monitor disease activity in HUS and TTP.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00868714
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