ISSN:
1420-9071
Keywords:
Hemorrhage
;
hypovolemic shock
;
hypotension
;
respiratory depression
;
protoveratrines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary In a rat model of severe hypotension and respiratory depression induced by step-wise bleeding, protoveratrines cause a prompt and sustained improvement of cardiovascular and respiratory functions, both in anesthetized and in conscious animals, seemingly through a magnification of the reflex response originated by the chemoreceptors of aortic and carotid bodies. The restoration of cardiovascular function is attributable to an increase both in total peripheral resistance and cardiac output. The finding could provide the basis for a new approach to the first-aid management of massive blood losses.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01939940
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