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Reversible hepatic dysfunction in association with cyclophosphamide therapy (1995)

Milford, David V. ; Butler, Nicola ; Clarke, Rachel ; [et al.]

Springer

European journal of pediatrics 154 (1995), S. 411-412

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ISSN: 1432-1076

Keywords: Cyclophosphamide ; Cimetidine ; Hepatic dysfunction

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract A 5.5-year-old child with nephrotic syndrome was treated with cyclophosphamide. After 9 weeks of therapy she developed jaundice and abnormal liver function tests. No infective aetiology was found and the abnormal liver function tests resolved within 5 weeks of discontinuing cyclophosphamide. Cyclophosphamide has rarely been reported to cause liver dysfunction, but not in children treated for nephrotic syndrome, and paediatricians should therefore be aware of its potential for inducing reversible hepatic dysfunction.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02072117

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