ISSN:
1432-0584
Keywords:
Bone marrow transplantation
;
Graft-versus-host-disease
;
Herpes viruses
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effects of pretransplant herpes virus serology on the occurrence of grades II–IV acute graft-versus-host disease (GVHD) were studied in 262 recipients and their HLA-identical family donors. In 131 recipients on standard GVHD prophylaxis (either methotrexate or cyclosporin A) significant effects were observed for donor HSV serology (seropositivity associated with increased risk for GVHD) and donor EBV serology (seronegativity associated with increased risk). However, these effects were nonsignificant in the other 131 recipients on intensified GVHD prophylaxis (i.e., methotrexate combined with cyclosporin A, in vivo anti-T-cell monoclonal antibodies, or various procedures to reduce the T-cell numbers in the transplants).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01715367
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