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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 416 (1990), S. 385-392 
    ISSN: 1432-2013
    Keywords: Acetylcholine receptor ; Membrane patch excision ; Channel kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Excision of membrane patches from clonal BC3H1 cells to the inside-out configuration reduces the mean open time and burst duration of skeletal muscle nicotinic acetylcholine receptors. The channel conductance is not altered. Our results indicate that the rates for several steps in receptor activation are affected. The altered receptors apparently form a homogeneous population. Patterns of activity similar to that seen after excision are seen infrequently in recordings from cell-attached patches, suggesting that receptors with this type of altered function are present in intact membranes. The extent and rate of the reduction in mean open time after excision are similar at acetylcholine concentration over a 1000-fold range, indicating that the alteration does not depend on the state of ligation of the receptor. The extent and rate also are similar at room temperature and at 11° C. The changes seen indicate that careful comparisons to intact preparations are necessary when studying the gating of channels in excised patches or following reconstitution into artificial membranes.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Dissektion ; Hirnnervenausfall ; Raeder-Syndrom ; Collet-Siccard-Syndrom ; Key words Dissection ; Cranial nerve deficiency ; Raeder's syndrome ; Collet-Sicard syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Acute cerebral nerve paresis can be caused in many different ways. One of the more rare causes of paresis of one or more neural pathways is dissection of the internal carotid artery. Early diagnosis is important, even with atypical symptoms, since prompt anticoagulative therapy can hinder stroke from embolism due to the dissection. We report on two patients with Raeder's syndrome and Collet-Sicard syndrome resulting from dissection of the internal carotid artery. Besides the cranial and caudal nerves involved in our study, loss of function has also been reported with the sixth to eighth cranial nerves, so that any painful, sudden cranial nerve deficiency can indicate possible carotid dissection
    Notes: Zusammenfassung Akute Hirnnervenparesen können eine Vielzahl von Ursachen haben. Seltener Auslöser einer Parese eines oder multipler Hirnnerven ist eine Dissektion der A. carotis interna. Die frühzeitige Erkennung einer Karotisdissektion auch bei untypischer Symptomatik ist wichtig, da eine rechtzeitig begonnene antikoagulatorische Therapie einen Schlaganfall als Folge einer dissektionsbedingten Embolie verhindern kann. Wir berichten über 2 Patienten mit Läsionen der parakavernösen Hirnnerven (Raeder-Syndrom) sowie der kaudalen Hirnnerven (Collet-Siccard-Syndrom) als Folge einer Dissektion der A. carotis interna. Neben den in unseren Fällen beteiligten kranialen und kaudalen Hirnnerven sind auch Ausfälle der mittleren Hirnnerven (VI–VIII) beschrieben worden, so dass jeder schmerzhafte plötzliche Hirnnervenausfall auch an eine Karotisdissektion denken lassen muss.
    Type of Medium: Electronic Resource
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