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  • 1
    Electronic Resource
    Electronic Resource
    Hypothalamic histamine modulates adaptive behavior of rats at high environmental temperature (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 283-285 
    Details
    ISSN: 1420-9071
    Keywords: Histamine ; hypothalamus ; environmental temperature ; adaptive behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Histamine content in the rat hypothalamus was lower at 4°C and higher at 31°C compared to that at 21°C. Pretreatment with α-fluoromethylhistidine, a ‘suicide’ inhibitor of histidine decarboxylase, attenuated both the increased level of hypothalamic histamine and rat adaptive behavior at 31°C. Increase of histamine content in the hypothalamus appears to be an important factor contributing to rat adaptive behavior to high environmental temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951767
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vivo release of neuronal histamine in the hypothalamus of rats measured by microdialysis (1991)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 343 (1991), S. 190-195 
    Details
    ISSN: 1432-1912
    Keywords: Histamine ; Neurotransmitter release ; Microdialysis ; α-Fluoromethylhistidine ; Thioperamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using an in vivo intracerebral microdialysis method coupled with an HPLC-fluorometric method, we investigated the extracellular level of endogenous histamine in the anterior hypothalamic area of urethaneanaesthetized rats. The basal rate of release of endogenous histamine in the anterior hypothalamic area measured by this method was 0.09 + 0.01 pmol/20 min. When the anterior hypothalamic area was depolarized by infusion of 100 mM K+ through the dialysis membrane or electrical stimulation at 200 μ A was applied through an electrode implanted into the ipsilateral tuberomammillary nucleus, histamine release increased to 175% and 188%, respectively, of the basal level. These increases were completely suppressed by removal of extracellular Ca2+. The basal release of histamine was also suppressed after infusion of 10−6 M tetrodotoxin or i.p. administration of 100 mg/kg of α-fluoromethylhistidine. On the other hand, 3-fold increase in the basal release was observed after i. p. administration of 5 mg/kg thioperamide. These results clearly indicate that both the basal and evoked release of histamine measured by our method are of neuronal origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168609
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of histamine N-methyltransferase-like structures in rat kidney (1986)
    Springer
    Cell & tissue research 243 (1986), S. 681-684 
    Details
    ISSN: 1432-0878
    Keywords: Histamine ; Histamine N-methyltransferase ; Immunohistochemistry ; Kidney ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Histamine N-methyltransferase (S-adenosylmethionine: histamine N-methyltransferase, E.C. 2.1.1.8) was purified to homogeneity from rat kidney, and antibody was raised against it in guinea pigs. The antibody immunoprecipitated histamine N-methyltransferase. Immunofluorescent histochemical studies with anti-histamine N-methyltransferase antibody as the first antibody and goat antiguinea pig IgG conjugated with fluorescein isothiocyanate as the second, showed the presence of immunoreactive structures in the proximal tubules of rat kidney. The brain showed no immunoreaction with the antibody.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218079
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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