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  • 1
    Electronic Resource
    Electronic Resource
    Development and cell kinetics of colonic tumors induced in mice by dimethylhydrazine (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 148-157 
    Details
    ISSN: 1432-1335
    Keywords: Dimethylhydrazine ; Adenoma ; Carcinoma ; Cell kinetics ; Histogenesis ; Colon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Colonic adenomas and carcinomas were induced in mice by intermittent injections of 1,2-dimethylhydrazine for 30 weeks and cell kinetic characteristics of different tumor types were studied by 3H-thymidine autoradiography. Labeling indices of adenomas and several carcinoma types after a single injection of 3H-thymidine were similar, both showing about 20%–23%. There was a tendency for the small adenomas and the poorly differentiated carcinomas to show higher labeling indices than the large adenomas and the well differentiated adenocarcinomas, respectively. By repeated injections of 3H-thymidine, it was shown that all adenoma and carcinoma cells became labeled within 60–70 h after the start of the injections, thereby suggesting a large growth fraction of the DMH-induced adenomas and carcinomas in the mouse colon. No remarkable differences in the labeling patterns were found between the adenomas and carcinomas, on the one hand, and intramucosal carcinomas and invasive carcinomas, on the other. The growth rate of the small adenomas appeared to be greater than that of the large adenomas and the poorly differentiated carcinomas may grow more rapidly than the well differentiated adenocarcinomas. The squamous-cell carcinomas arising in the anal region were shown to grow more rapidly than the adenocarcinomas of the colon. The changing patterns of tumor development were also studied at various times after DMH treatment with special reference to the minute neoplasms and their histogenesis and it was shown that the adenoma cells arising in the crypts accumulate in the upper part of the crypt to form an aberrant proliferative focus from which a neoplasm develops by expansion. The lesions considered to be benign on histological grounds may possibly change into adenocarcinomas of a well differentiated type. The poorly differentiated carcinomas were suggested to arise as de novo malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406925
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  • 2
    Electronic Resource
    Electronic Resource
    ’Pyloric gland-type adenoma’ arising in heterotopic gastric mucosa of the duodenum, with dysplastic progression of the gastric type (1999)
    Springer
    Virchows Archiv 435 (1999), S. 452-457 
    Details
    ISSN: 1432-2307
    Keywords: Key words Pyloric gland-type adenoma ; Heterotopic gastric mucosa ; Duodenum ; Mucin ; Histogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  ’Pyloric gland-type adenoma’ is a recently described and very rare entity. We report a case of a pedunculated polyp of the duodenal bulb showing the features of pyloric gland-type adenoma. Heterotopic gastric mucosa was found adjacent to the tumour. Immunohistochemically, the tumour cells at the surface of the polyp showed foveolar-type mucin (M1) while most other tumour cells showed deep gastric mucin (M2), displaying a pattern of differentiation similar to the normal gastric mucosa. The polyp also showed villous or papillary structures with disorganization of gastric differentiation and marked increase of proliferating in foci cells. This is the first case of pyloric gland-type adenoma found to arise in heterotopic gastric mucosa of the duodenum, showing dysplastic progression of the gastric type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050425
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  • 3
    Electronic Resource
    Electronic Resource
    Fusion of particulate structure in polyvinyl chloride during powder extrusion (1972)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 12 (1972), S. 199-203 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: It has been recognized recently that suspension polyvinyl chloride granules consist of particles ca 1μ in diam which are linked together to form a three-dimensional, sponge-like lattice. This paper deals with the fusion process of this particulate structure of PVC resin during powder extrusion. Extrudates prepared under various extrusion conditions are investigated through the electron microscope using a methyl methacrylate (MMA) embedding method followed by ultrathin sectioning. The MMA embedding method has been proven to be an effective means of revealing the detailed structure of molded PVC. Results showed that the 1μ-particles were subjected to breakdown due to heat and shear into fibrils 100-300 Å in thickness, which were the final structure attainable by extrusion. Discussion was focused on the fibrillar structure especially in relation to the elasticity in plasticized PVC.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760120307
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  • 4
    Electronic Resource
    Electronic Resource
    Raman optical activity of some azo dyes induced by inclusion in cyclodextrins (1987)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 18 (1987), S. 153-155 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Raman optical activity (ROA) spectra of some azo dyes binding to cyclodextrins have been measured. This appears to be the first successful attempt to measure the ROA induced in achiral molecules by intermolecular interaction with chiral molecules. There was no relationship between the ROA signals and the Raman shifts accompanying inclusion phenomenon. From comparison of the ROA spectra of methyl orange with α-cyclodextrin and congo red with γ-cyclodextrin, it seems that the ROA spectra reflect the difference in the positions of the SO3- groups in the guest molecules.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250180302
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    Paper (German National Licenses)
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