ISSN:
1573-2592
Keywords:
Human T-lymphotropic virus Type I
;
systemic lupus erythematosus
;
serum antibody
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Twenty-six percent of 53 systemic lupus erythematosus sera had high levels of IgM antibody to human T-lymphotropic virus Type I, significantly more than the 5% of normal controls. Neither IgG antibodies to Type I virus nor IgM or IgG antibodies to Type II virus were increased in lupus. Further analysis using competition immunoassay and Western blot techniques also suggested that the IgM Type I antibodies in lupus sera were directed against viral antigens but did not completely exclude a nonviral reaction. Other studies also have not found IgG antibodies to the Type I virus but have not tested for IgM antibodies. Our study suggests that human T-lymphotropic virus Type I or a related virus may be involved in the pathogenesis of some cases of systemic lupus erythematosus.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00918703
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