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  • 1
    Electronic Resource
    Electronic Resource
    White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 421-424 
    Details
    ISSN: 1432-0533
    Keywords: Key words Membrane-type matrix metalloprotease ; Gelatinase A ; Human brain ; Microglia ; β-Amyloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Membrane-type matrix metalloprotease (MT-MMP) is an activator of gelatinase A (MMP-2), which has previously been found in carcinoma cells. We examined non-neurological and Alzheimer's disease brain tissues for MT-MMP by immunohistochemistry and in situ hybridization. The anti-MT-MMP antibodies gave positive staining of brain microglial cells in all the brain tissues. Positively stained microglia were found only in the white matter. The cells producing MT-MMP protein were also shown to be white matter microglia. These results provide further evidence that activated gelatinase A, which may be a processing enzyme for degradation of β-amyloid protein, may be produced in white matter microglia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294800
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  • 2
    Electronic Resource
    Electronic Resource
    White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 421-424 
    Details
    ISSN: 1432-0533
    Keywords: Membrane-type matrix metalloprotease ; Gelatinase A ; Human brain ; Microglia ; β-Amyloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Membrane-type matrix metalloprotease (MT-MMP) is an activator of gelatinase A (MMP-2), which has previously been found in carcinoma cells. We examined non-neurological and Alzheimer's disease brain tissues for MT-MMP by immunohistochemistry and in situ hybridization. The anti-MT-MMP antibodies gave positive staining of brain microglial cells in all the brain tissues. Positively stained microglia were found only in the white matter. The cells producing MT-MMP protein were also shown to be white matter microglia. These results provide further evidence that activated gelatinase A, which may be a processing enzyme for degradation of β-amyloid protein, may be produced in white matter microglia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294800
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Expression of the membrane-type 3 matrix metalloproteinase (MT3-MMP) in human brain tissues (1998)
    Springer
    Acta neuropathologica 96 (1998), S. 347-350 
    Details
    ISSN: 1432-0533
    Keywords: Key words Membrane-type 3 matrix metalloproteinase ; Gelatinase A ; Human brain ; Microglia ; Reverse ; transcriptase-polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Membrane-type 3 matrix metalloproteinase (MT3-MMP) is a novel MT-MMP which has a transmembrane domain at the C terminus, and mediates activation of pro-gelatinase A, just as does MT1-MMP. Previously, we reported that MT1-MMP was expressed on microglial cells only in the white matter [Yamada T, Yoshiyama Y, Sato H, Seiki M, Shinagawa A, Takahashi M (1995) Acta Neuropathol 90 : 421–424]. In the present study of both non-neurological and Alzheimer brain tissues, we examined the localization of MT3-MMP by immunohistochemistry. Anti-MT3-MMP antibodies gave positive staining of microglial cells in all brain tissues. Positively stained microglia were found not only in the white matter but also in the gray matter. Reverse transcriptase-polymerase chain reaction for MT3-MMP mRNA showed the same amount of expression in gray and white matters, while that for gelatinase A and MT1-MMP mRNA expressed much higher in the white matter than in the gray matter. These results suggest that MT3-MMP may play a role on microglial cells, although its role may be different from MT1-MMP in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050904
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  • 4
    Electronic Resource
    Electronic Resource
    Three-phase carboxylation reactions of poly(chloromethylstyrene) beads with sodium nitrite (1987)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 188 (1987), S. 1383-1389 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The formation of carboxylic acid groups (carboxyl + ester groups) was found in a threephase reaction of crosslinked poly(chloromethylstyrene) beads with an excess amount of sodium nitrite in immiscible solvents of benzene and water with tetrabutylammonium bromide as a phase transfer catalyst (PTC), and the dependence of carboxylic acid yield on the experimental conditions was studied. The product contains hydroxyl groups and ester bonds besides carboxyl groups. It was tentatively considered that the carboxyl groups are produced by direct oxidation of chloromethylstyrene groups by nitrous anions. Nitrous anions do not only act as a nucleophile but also as an oxidative reagent in this case.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1987.021880614
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  • 5
    Electronic Resource
    Electronic Resource
    Characteristic viscoelastic parameters for amorphous polymers (1963)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 7 (1963), S. 1341-1347 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: By use of a reference value of modulus equal to 109 dynes/cm.2 and a reference value of time equal to 10 sec., characteristic viscoelastic parameters are defined from stress relaxation master curves and from modulus-temperature curves. Values of these parameters are tabulated for several linear amorphous polymers and slightly crosslinked amorphous polymers.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1963.070070414
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  • 6
    Electronic Resource
    Electronic Resource
    Analysis of crude drugs by pyrolysis gas chromatography (1985)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 8 (1985), S. 360-361 
    Details
    ISSN: 0935-6304
    Keywords: Pyrolysis gas chromatography ; Fused silica open tubular column ; Crude drugs ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240080708
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  • 7
    Electronic Resource
    Electronic Resource
    Preparation of amidinourea from hydroxymethyl cyanoguanidine: a model reaction of cyanoguanidine resin (1993)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 4 (1993), S. 561-563 
    Details
    ISSN: 1042-7147
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1993.220040906
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  • 8
    Electronic Resource
    Electronic Resource
    Properties of RecA-oligonucleotide complexes (1994)
    Chicester [u.a.] : Wiley-Blackwell
    Journal of Molecular Recognition 7 (1994), S. 199-206 
    Details
    ISSN: 0952-3499
    Keywords: RecA ; Homologous recombination ; DNA-protein complexes ; Isoelectric focusing ; Linear dichroism ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The interaction of RecA protein with short single-stranded oligonucleotides is characterised by flow linear dichroism (LD), isoelectric focusing (IEF) and electron microscopy (EM). From LD and EM it is evident that RecA forms long filaments with at least some 50 oligonucleotides in a ‘train formation’. The tendency to form trains is substantially lower when an amino group is attached to the 5′ end of the oligonucleotide, suggesting that the modification impairs protein-protein interactions at the interface between two oligomers. From LD it is also evident that no bridging occurs between RecA-Oligonucleotide complexes containing more than one oligomer strand per RecA filament. This property make them manageable in polyacrylamide gels, hence allowing characterisation by IEF. RecA was found acidic with a pI of 5.0. The pI was not dependent on the presence of bound cofactor (ATPγS) and oligonucleotides suggesting that protonation of the protein readily occurs to compensate for the negative charges provided by bound cofactor and DNA.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmr.300070307
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  • 9
    Electronic Resource
    Electronic Resource
    Kinetic study of cyanoguanidine resin formation: acid hydrolysis of hydroxymethyl and methoxymethyl cyanoguanidine (1993)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 4 (1993), S. 555-560 
    Details
    ISSN: 1042-7147
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The hydrolysis of hydroxymethyl cyanoguanidine and methoxymethyl cyanoguianidine in acidic aqueous media were studied by analyzing the eluted formaldehyde and the reaction products. Dihydroxymethyl cyanoguanidine released two formaldehydes with different rates because one of the two hydroxymethyl groups is intramolecularly interactive through the hydrogen bond. Methanol dissociation from methoxymethyl cyanoguanidine was seven to eight times faster than the dissociation of hydroxymethyl group, and the overall hydrolysis kinetics were similar to those of hydroxymethyl cyanoguanidine.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1993.220040905
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  • 10
    Electronic Resource
    Electronic Resource
    Master curves for some amorphous polymers (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 8 (1964), S. 1549-1561 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Master curves for polystyrene, poly(methyl acrylate), and poly(methyl methacrylate) in stress relaxation are reported. The method used to obtain a wide range in modulus is to combine torsional creep data for high modulus regions with direct stress relaxation data for low moduli. The composite curves obtained are compared with existing literature data. The master curve for polystyrene obtained by a ball indentation method is also reported. Characteristic viscoelastic parameters derived from the data are tabulated.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1964.070080405
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