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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 104 (1991), S. 67-69 
    ISSN: 1437-1596
    Keywords: Triazolam ; Estazolam ; Capillary GC/NPD ; Human tissue ; Forensic toxicology ; Triazolam ; Estazolam ; Kapillar-Gaschromatographie/NPD ; Menschliches Gewebe ; Forensische Toxikologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Eine zuverlässige und empfindliche Methode wurde entwickelt, um die Konzentrationen des hypnotischen Medikaments Triazolam in menschlichen Geweben, einschließlich fauler Gewebe bestimmen zu können. Die Methode besteht aus einer dreistufigen Flüssig-Flüssig-Extraktion, einem Clean up an Kieselgel und Gaschromatographie mit einem Stickstoff-PhosphorDetektor und einer Kapillarsäule. Als interner Standard wurde Estazolam benutzt. Die Eichkurve war im Konzentrationsbereich zwischen 1 ng/g und 1 gg/g linear, und die untere Nachweisgrenze betrug 0.5 ng/g. Es wurde eine forensische Untersuchung über die toxikologischen Effekte von Triazolam an faulem Gewebe durchgeführt.
    Notes: Summary A reliable and sensitive method has been developed to assess the concentrations of the hypnotic drug triazolam in human tissues, including putrefied tissues. The method involves a 3-step solvent extraction, cleanup on a silica gel column and gas chromatography using a nitrogen phosphorus detector and a capillary column. Estazolam was used as an internal standard. The calibration curve was linear over the concentration range 1 ng/g1 gm/g and the lower limit of detection was 0.5 ng/g. A forensic study was performed on the toxicological effects of triazolam using putrefied tissues.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 109 (1996), S. 42-44 
    ISSN: 1437-1596
    Keywords: Toxicology ; Drowning ; Sulfides ; Human tissue ; Distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract An adult male was found dead beneath a pool of sewage in the pump room of a fish market. Autopsy revealed the cause of death to be suffocation after aspirating sewage into the respiratory tract. Since hydrogen sulfide gas was detected in the atmosphere at the scene of the accident, gas poisoning was suspected and toxicological analysis of sulfides in body tissues was performed. The concentrations of sulfides in the blood, lung and kidney were 0.95 μmol/ml, 0.22 and 0.38 μmol/g, respectively. These values were remarkably higher than those in previously reported cases involving exposure to hydrogen sulfide gas. Therefore, oral intake of sulfides was assumed and the distribution of sulfides in tissues following oral administration of sodium sulfide solution was examined by means of animal experiments using rats. The concentration of sulfides in the blood from rats following oral intake was much higher than that seen following gas exposure. Based on these results, we concluded that the victim had been exposed to hydrogen sulfide gas and had then collapse into a pool of sewage containing sulfides. The sulfides which were distributed throughout the body tissues had mainly issued from the alimentary tract prior to death by drowning.
    Type of Medium: Electronic Resource
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