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  • 1
    Electronic Resource
    Electronic Resource
    Acute and chronic effects of carbamyl glutamate on blood urea and ammonia (1985)
    Springer
    European journal of pediatrics 143 (1985), S. 196-197 
    Details
    ISSN: 1432-1076
    Keywords: Carbamyl glutamate ; Urea cycle disorders ; Hyperammonaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Carbamyl glutamate injected into normal rats produced no change in blood urea levels. Rats fed a high-protein dict or starved for 48 h had increased blood urea. Carbamyl glutamate injection induced a further increase in the levels of urea in their blood. Also, carbamyl glutamate administered in the drinking water of normal mice produced an increase in blood urea, which was accompanied by a decrease in blood ammonia. The application of these findings to the treatment of urea cycle enzymopathies is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442137
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Carbamyl glutamate prevents the potentiation of ammonia toxicity by sodium benzoate (1989)
    Springer
    European journal of pediatrics 148 (1989), S. 540-542 
    Details
    ISSN: 1432-1076
    Keywords: Sodium benzoate ; Hyperammonaemia ; Carbamyl derivatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sodium benzoate has been recommended for the treatment of hyperammonaemia in humans. However, benzoate potentiates ammonia toxicity and reduces urea synthesis in vitro and in vivo by decreasing the intramitochondrial levels of N-acetyl glutamate. Pretreatment of mice with carbamyl glutamate, a structural analogue of N-acetyl glutamate, decreases mortality induced by ammonium acetate and sodium benzoate administration. The protective effect of carbamyl glutamate is accompanied by an increase in urea production and of carbamyl phosphate synthetase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441553
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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