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  • 1
    Electronic Resource
    Electronic Resource
    Nuclear inclusions in immature glial cells of the rat hypothalamus during the postnatal period (1983)
    Springer
    Anatomy and embryology 167 (1983), S. 263-271 
    Details
    ISSN: 1432-0568
    Keywords: Nuclear inclusions ; Immature glial cells ; Hypothalamus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural study of the hypothalamic ventromedial nucleus during the postnatal period showed the presence of nuclear inclusions in immature glial cells. These inclusions, identified as “coiled bodies”, consist of round-to-oval formations of coiled electron-dense strands embedded in a less dense fibrillar matrix. Coiled bodies are located free within the nucleoplasm, showing no specific relationships with the nucleolus or the nuclear membrane. The cells containing coiled bodies were typified as oligodendrocyte precursors, mainly oligodendroblasts. The coiled bodies were not found in mature glial cells nor in other types of immature glial elements. The nature and possible functional role of coiled bodies are suggested in the light of recent morphological and biochemical data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00298515
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Silver staining of the neuronal nucleus in electron microscopy: Nucleolar organization in supraoptic nuclei of the rat hypothalamus (1981)
    Springer
    Anatomy and embryology 163 (1981), S. 265-273 
    Details
    ISSN: 1432-0568
    Keywords: Silver staining ; Neurons ; Nucleolus ; Supraoptic nucleus ; Hypothalamus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present paper describes a simple, efficient method for silver impregnation of supraoptic nuclei of the rat hypothalamus using a modification of the ammoniacal silver technique of Cajal (1903). This procedure, involving a silver-developer sequence in tissue blocks prior to plastic embedding, permits the simultaneous study of Ag-impregnated supraoptic neurons at both light and electron microscopic levels. Visualization of secretory magnocellular neurons impregnated by this technique using the electron microscope reveals a good preservation of nuclear structures. A selective accumulation of silver grains was observed over heterochromatin clumps and nucleoli, which allows the identification of the nucleolar fibrillar centers and also the dense fibrillar component as the main areas involved in the silver reaction. The meaning of such a silver-distribution pattern is discussed in the light of recent ultrastructural and biochemical data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315704
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of age on nuclear bodies and nuclear volume in pituicytes of the rat neurohypophysis (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 230 (1991), S. 319-324 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: This study has analyzed age-related changes in the nuclear organization of pituicytes of the rat. The cytological study of the cell nucleus and the quantitative analysis of nuclear bodies (NBs) were performed on ultrathin sections. Nuclear diameter, perimeter, and area were measured on semithin sections, and nuclear volume was estimated from these data. The nucleolus was mainly composed of a few large fibrillar centers with their associated dense fibrillar component, whereas the granular component tended to form large masses at the nucleolar periphery. The most frequent configuration of NBs was a globular inclusion composed of a fibrillar capsule with a core that contained a few electron-dense granules. Intranuclear glycogen was detected on rare occasions and only in old rats. The proportion of nuclear sections containing NBs increased significantly from 1.5% in 3-month-old rats to 8.6% in 18-month-old rats. A significant increase in the nuclear volume was detected in older rats with respect to the younger ones (157±69 vs. 98±43 μm3, mean ±S.D.). Our results suggest an age-related activation of nuclear metabolism in pituicytes resulting in a nuclear expansion and an increase in the frequency of appearance of NBs. This activation might be a reactive cellular event induced by the degenerative changes in neurosecretory nerve endings naturally occurring in older animals.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092300304
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Coiled bodies in supraoptic nuclei of the rat hypothalamus during the postnatal period (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 159 (1980), S. 447-454 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In electron microscopic studies of the supraoptic nuclei of the rat hypothalamus, structures identified as “coiled bodies” were found in magnocellular neurons. Although they could be seen elsewhere in mature neurosecretory cells, coiled bodies were commonly encountered in developing neurons during the postnatal period in both sexes. They appeared as distinctive nuclear inclusions consisting of round-to-oval networks of short electron-dense strands embedded in a less dense, fibrillar matrix, and lacking a limiting membrane. In fine structure and stain-affinity, they bore a resemblance to the fibrillar component of the nucleolus.Coiled bodies were located either in close association with the nucleolus or free within the nucleoplasm, showing no specific relationships with the perinucleolar chromatin or with the nuclear envelope. Their origin and functional meaning is discussed in the light of recent ultrastructural and biochemical data on cellular differentiation and nucleolar behavior.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001590408
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    Paper (German National Licenses)
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