ISSN:
1432-1912
Keywords:
Key wordsβ1-adrenoceptor
;
β2-adrenoceptor
;
Guinea-pig ventricular myocardium
;
Positive inotropic effect
;
Atenolol
;
ICI 118.551
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In guinea-pig isolated papillary muscles we studied the positive inotropic effects of the β-adrenoceptor agonists isoprenaline, fenoterol and noradrenaline in the presence and absence of the β1-selective antagonist atenolol and the β2-adrenoceptor antagonist ICI 118.551. In Schild regression analysis pA2 values for either atenolol (7.14–7.16) and ICI 118.551 (6.79–6.84) were independent of the agonists used. These results support the view that the inotropic response in guinea-pig ventricular myocardium is mediated by β1-adrenoceptors only.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00004920
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