ISSN:
1573-2568
Keywords:
ENPROSTIL
;
OMEPRAZOLE
;
HYPERGASTRINEMIA
;
INTRAGASTRIC PH MEASUREMENT
;
HELICOBACTER PYLORI
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract This study was performed to examine the effectsof additional enprostil administration onhypergastrinemia and gastric acid suppression induced byomeprazole. Serum gastrin concentrations were measured in 10 peptic ulcer patients (six Helicobacterpylori-positive and four Helicobacter pylori-negativepatients) before treatment, after two weeks ofomeprazole (20 mg/day), and after two weeks ofomeprazole and enprostil (50 μg/day). The additionalacid inhibitory effect of enprostil was evaluated by24-hr intragastric pH measurements in five healthyHelicobacter pylori-negative volunteers. Afteromeprazole treatment, the serum gastrin level ofHelicobacter pylori-positive patients (3.5-fold ofcontrol) was markedly higher than that of Helicobacterpylori-negative patients (1.7-fold of control).Additional treatment with enprostil suppressed serumgastrin levels to 0.4-fold and 0.7-fold of omeprazoletreatment levels in Helicobacter pylori-positive andHelicobacter pylori-negative patients, respectively. In healthy volunteers, median pH recordedduring the nonmeal daytime interval increasedsignificantly with additional enprostil. Thus, enprostilreduces undesirable omeprazole-induced hypergastrinemia, especially in Helicobacter pylori-positivepatients, and effectively suppresses acidsecretion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018825902055
Permalink
