ISSN:
1438-2199
Keywords:
Amino acids
;
Chemotactic peptides
;
Structure/activity relation-ship
;
CD
;
IR
;
Conformation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In order to investigate the proper peptide backbone conformation able to elicit a biological activity, HCO-Met-Pro-Phe-OMe, HCO-Met-Ψ[COO]Leu-Phe-OMe, and HCO-Met-OLeu-Phe-OMe, analogues of the prototypical chemotactic peptide HCO-Met-Leu-Phe-OMe, were studied by CD and IR techniques. The results obtained comparing biological and conformational data evidence the critical presence of (i) the NH group at position 2, (ii) a rather flexible backbone, (iii) the chemical structure of the central residue which can affect the stability of a possible active conformer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00807274
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