ISSN:
1432-1076
Keywords:
IgA deficiency
;
Atopy
;
Infection
;
Chromosome defects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Fifty children with IgA deficiency were followed for 1 to 4 years from 1975 to 1978. Thirty-five had complete deficiency of serum IgA (〈2.5 IU/ml) and 15 partial deficiency (serum IgA below the 10th centile for age). Patients with another associated immunodeficiency, such as ataxia-telangiectasia, were not included. Most children with complete deficiency of IgA had recurrent respiratory and/or gastrointestinal infections, about half with onset in the first year of life, while partial deficiency of IgA has probably little if any importance for anti-infectious immunity but is important in the pathogenesis of atopy. Atopic diseases were frequent in both groups. Chromosomal abnormalities were found in 2 patients: trisomy 21 in one and in the other a ring chromosome 18. No important defects in cellular immunity were detected but some isolated, borderline abnormalities were often present.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00441577
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