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Neuropathy in igMλ paraproteinemia (1989)

Yee, W. C. ; Hahn, A. F. ; Hearn, S. A. ; [et al.]

Springer

Acta neuropathologica 78 (1989), S. 57-64

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ISSN: 1432-0533

Keywords: Neuropathy ; IgMλ paraproteinemia ; Antigen-specificity ; Endoneurial compartment ; Endothelial-perineurial barrier

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary In axonal neuropathies associated with IgM paraproteinemia, reports of antigen specificity of the M-protein are few. A patient with IgM paraproteinemia presented with progressive mononeuritis multiplex. IgM was found deposited in striking amounts in endoneurium and shown to bind specifically to neural proteins and chondroitin sulfates. Direct immune mechanisms, as well as the physical effects of IgM deposition, likely contributed to the development of the neuropathy.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00687403

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