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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 279-281 
    ISSN: 1432-1440
    Keywords: Metronidazole ; Bile acids ; Cholesterol absorption ; Serum cholesterol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five patients with Crohn's disease long-term therapy with metronidazole (400 mg b.i.d.) was followed by a significant reduction of total serum cholesterol from 179 mg/dl to 156 mg/dl, 134 mg/dl, and 143 mg/dl, after 2–4 months, 6 months, and 9–12 months, respectively. Lipoprotein analysis before and after 3 weeks of administration of metronidazol (400 mg/day) to five normolipemic volunteers revealed that LDL-cholesterol was reduced by 21% (P〈0.05), whereas HDL-cholesterol remained unchanged. Biliary secretion of cholesterol and bile acids were reduced by 13% and 20% (P〈0.05), respectively, which might suggest a decreased sterol synthesis. The amount and percentage of intestinal cholesterol absorption were decreased by 33% and 22% (P〈0.05). Thus, a possible decrease in sterol synthesis and a reduction of cholesterol absorption might be responsible for the serum-cholesterol-lowering effect of metronidazole. However, caution should be taken when considering metronidazole for long-term treatment of patients with hypercholesterolemia due to possible side effects.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 143 (1984), S. 35-40 
    ISSN: 1432-1076
    Keywords: Chronic intrahepatic cholestasis ; Biliary lipid composition ; Bile acids ; Gallstones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Biliary lipid composition, standard liver function tests, serum lipids and faecal fat excretion were studied in 15 children with chronic intrahepatic cholestasis (severe intrahepatic cholestasis, n=6; paucity of intralobular bile ducts, n=4; benign recurrent cholestasis, n=5) and compared to 15 children without gastrointestinal diseases. Severe and benign intrahepatic cholestasis were associated with normal or moderately elevated serum lipids. Biliary lipid concentrations were extremely reduced, bile acid concentrations were below the critical micellar concentration. This may account for the high incidence of gallstone formation in these patients. Remission periods in patients with benign recurrent cholestasis were not followed by complete normalisation of biliary lipid concentrations, indicating a primary defect in hepatic excretory function. Children with paucity of intralobular bile ducts showed markedly increased serum lipids, but only a two-fold reduction in biliary lipid concentrations. Cholic acid was the predominant bile acid in bile of all cholestatic children even during remission. Neither increased levels of monohydroxy bile acids nor unusual bile acids could be identified in notable amounts.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 143 (1984), S. 41-44 
    ISSN: 1432-1076
    Keywords: Chronic intrahepatic cholestasis ; Biliary lipid composition ; Bile acids ; Phenobarbital
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of phenobarbital (5.4–7.5 mg/kg body weight) for 14 days were studied in four children with severe intrahepatic cholestasis (group I) and in four with a syndromatic type of paucity of intralobular bile ducts (group II). Phenobarbital administration resulted in a moderate improvement of pruritus in all patients. There was a significant decrease of bilirubin in serum (group I: from 4.8 to 2.7 mg/dl; group II: from 6.1 to 2.1 mg/dl); total bile acids (group I: from 416 to 337 μmol/l; group II: from 156 to 123 μmol/l) and cholesterol (group I: from 248 to 207 mg/dl; group II: from 351 to 292 mg/dl). Alkaline phosphatase activity increased from 929 to 1126 U/l in group I and from 1751 to 2360 U/l in group II. SGOT and SGPT activities remained unchanged in both groups. In group I total biliary lipid concentration and bile acid output increased from 0.09 to 0.17 g/dl and from 3.9 to 7.2 μmol/kg per 30 min, respectively. Molar percentages of cholesterol, phospholipids and bile acids in bile remained unchanged. In group II total lipid concentrations and bile acid output increased from 1.62 to 2.0 g/dl and from 27.8 to 39.1 μmol/kg per 30 min, respectively. The molar percentage of cholesterol decreased from 5.6 to 3.5 mol%. The present results indicate that short term administration of phenobarbital has only minimal effects on biliary lipid metabolism in children with chronic intrahepatic cholestasis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 471-471 
    ISSN: 1435-2451
    Keywords: Ileal resection ; Biliary secretion ; Cholesterol gallstone formation ; Ileumresektion ; biliäre Sekretion ; Cholesteringallensteinbildung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Patienten mit Resektion des terminalen Ileums weisen eine erhöhte Incidenz von Cholesteringallensteinen auf. Zur Aufklärung des Mechanismus der Steinbildung wurde bei 5 Patienten mit Ileumresektion (mehr als 120 cm) und bei 5 Kontrollpersonen die biliäre Lipidsekretion über 24 h gemessen. Die biliäre Sekretion von Gallensäuren (GS), Phospholipiden (PL) und Cholesterin (CH) war bei den resezierten Patienten um 52 %, 53 % bzw. 47 % erniedrigt. Die Reduktion der CH-Sekretion war nicht so ausgeprägt wie die von GS und PL. Aus diesem Grunde war die Galle bei Ileumresezierten 14 h am Tag mit CH übersättigt, im Gegensatz zu 7h bei den Kontrollpersonen (p 〈 0,0s1).
    Notes: Summary Patients with resection of the ileum are at increased risk of forming cholesterol gallstones. In order to investigate the underlying mechanism of stone formation, biliary lipid secretion was measured for 24 h in five patients after ileal resection (more than 120 cm) and five controls. The biliary secretion of bile acid (BA), phospholipids (PL), and cholesterol (CH) in ileal resected patients was reduced by 52%, 53%, and 47%, respectively. The reduction in cholesterol secretion rate was not as much as that of BA and Pl. As a result, the bile in patients with ideal resection was supersaturated with CH for 14h in contrast to 7 h in control subjects (p 〈 0.01).
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 549-549 
    ISSN: 1435-2451
    Keywords: Resection of the ileum ; Postoperative symptomes ; Ileumresektion ; Postoperatives Beschwerdebild
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Erfassung des klinischen Beschwerdebildes dünndarmresezierter Patienten wurden von 197 Patienten mit isolierter Dünndarmresektion aus den Jahren 1958-1978 der Chirurgischen Universitäts Klinik Bonn 68 Patienten befragt und die Ergebnisse ausgewertet. Von diesen wurde bei 14 Patienten weniger als 30 cm Ileum reseziert, bei 21 Patienten 30- 80 cm, bei 19 Patienten 80-150 cm und bei 9 Patienten mehr als 150 cm. Bei 5 Patienten wurden 80 cm Jejunum reseziert. 53 (77,9%) der befragten Patienten gaben z. Z. der Entlassung Durchfälle an. Bei 16 Patienten (23,5%) trat postoperativ keine Besserung ein, bei 26 Patiente (38,2%) dauerte die Adaptation 3 Monate bis zu 1 Jahr. Zwischen Resektatlänge und Stuhlfrequenz sowie allgemeinem Beschwerdebild fand sich bei fast allen Gruppen eine Korrelation.
    Notes: Summary To document the clinical symptoms after partial resection of the small intestine 68 patients of a total of 197 patients operated during the period of 1958-1978, Department of Surgery, University of Bonn, were evaluated for their postoperative symptoms. Of the 68 patients 14 had a resection of less than 30 cm of the ileum, 21 patients of 30–80cm, and 9 more than 150cm. Five patients had undergone a resection of 80 cm of jejunum. Of these patients 53 (78%) had diarrhea at the time of discharge from the hospital. A normalisation of the bowel movement appeared after 3 to 12 months in 26 patients (38%),16 patients (24%) experienced no improvement at all. A correlation between the length of intestinal resection and requency of bowel movements as well as general symptoms was found in all groups of patients.
    Type of Medium: Electronic Resource
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