ISSN:
1432-1041
Schlagwort(e):
Imipramine
;
Paediatrics
;
population pharmacokinetics
;
enuresis
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary The population pharmacokinetics of imipramine (IMI) and its active metabolite desipramine (DMI) have been evaluated using 177 IMI and DMI serum levels from 49 enuretic children (6–13 y) on IMI treatment. Standard two stage (STS) and maximum likelihood (ML) methods were used to estimate fixed and random effect parameters of IMI. Simultaneous estimation of the drug and metabolite parameters was carried out by the STS method. The mean value of the elimination constant of the drug and metabolite were 0.0425 h−1 and 0.0359, h−1 respectively. Significantly higher variability was found in the pharmacokinetic parameters of the metabolite. According to these estimated pharmacokinetic parameters, the recommended dose for enuretic children should be 1.7 mg · kg−1 · day−. The population pharmacokinetic parameters obtained in the study permit dosage individualisation using a bayesian algorithm.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02280761
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