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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 8 (1988), S. 113-117 
    ISSN: 1437-160X
    Keywords: Ross River virus ; Polyarthritis ; Immune complexes ; Complement ; Rheumatoid factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immune complexes were sought in serum and synovial fluid in Ross River virus disease (epidemic polyarthritis). Multiple samples from 15 patients showing varied degrees of disease activity over a 3 month period were analysed for their content of complement components C3 and C4, and for C1q solid-phase and Raji cell binding activity. Levels of C3 and C1q binding activity were normal. C4 and Raji cell binding activity were normal except for three high levels of Raji cell binding, of which two were accompanied by low levels of C4, with normal C3 and C1q binding. Synovial fluid showed anomalous Raji cell reactivity of uncertain significance. Conglutinin solid-phase binding activity and IgG rheumatoid factor were compared in the serum of 20 patients during active disease and after recovery. The results were identical and within the normal range in both phases. One patient developed IgM rheumatoid factor in a low titre late in his illness. Although these findings do not entirely exclude a role for immune complexes formed at the onset in the circulation or tissues, it is concluded from this and other evidence that circulating complexes are not commonly responsible for the persistence of syndroms in this disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 2 (1983), S. 13-17 
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Spontaneous Nasal Septal Perforation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nasal septal perforation is known to be associated with various traumatic and disease states, yet spontaneous nasal septal perforation (SNSP) is relatively rare. SNSP has been reported in three patients with seropositive rheumatoid arthritis (RA) and we report an additional seven patients with SNSP and RA, four of whom were seronegative and none of whom had Raynaud's, in contrast to those reported previously. Manifestations of overt infectious, neoplastic or granulomatous disease have not been found in our seven patients over several years of close follow-up. We have identified no obvious pathogenesis or specific etiology for SNSP. We suggest that SNSP may represent an unusual manifestation of RA previously not well recognized.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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