ISSN:
1432-2307
Keywords:
Endothelial cells
;
Monocyte
;
Liver
;
Immunohistochemistry
;
Monoclonal antibodies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary During studies of the antigenic and functional properties of hepatic sinusoidal lining cells in situ, we found that only the sinusoidal endothelial cells share antigens with a peripheral blood macrophage subset capable of presenting soluble antigens and triggering autologous mixed lymphocyte reactions. They were HLA-DR+, OKM1−, OKM5+. Vascular endothelial cells in the portal areas and central veins were HLA-DR+, OKM1− and OKM5−. The sinusoidal endothelial cells also expressed an antigen found on helper/inducer (OKT4 and Leu3 a) T lymphocytes. Thus, the present study suggests that endothelial cells in different anatomic compartments in the liver heterogenously express surface antigens associated with monocytes, macrophages and T lymphocytes and possess distinct immunological functions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00705413
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