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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 675-688 
    ISSN: 1432-1440
    Keywords: Immunohistology ; Skin alterations ; Graft-versus-host disease ; Bone marrow transplantation ; Langerhans cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Skin biopsies of 26 patients with leukemia and seven patients with aplastic anemia were investigated before and at different stages after allogeneic bone marrow transplantation (BMT) to establish the immunological criteria which distinguish skin alterations during normal reconstitution from dermal lesions mediated by graft-versushost disease (GvHD). Of the 33 patients studied 27 presented with clinically diagnosed acute and/or chronic GvHD, one patient died of bone marrow rejection. Immunohistological analysis of the respective skin biopsies with selected monoclonal antibodies against human leukocyte antigens (HLA) and differentiation antigens of the lympho-hematopoietic cells revealed low dermal mononuclear cell counts with phenotypically normal constituents in five cases with uncomplicated reconstitution post-grafting. In contrast, increased dermal cellular infiltrates predominantly consisting of Lyt 3+, OKT 8+ T-lymphocytes, as well as of a large number of Ia-like (immune response associated = HLA-D) determinant+ monocytes/macrophages were observed in all patients with active acute/chronic GvH reactivity. As sign of activation simultaneous expression of HLA-D region products was also found on a subset of the invading OKT 8+ T-lymphocytes. Progression of GvHD was associated with additional surface staining of keratinocytes for Ia-like determinants. Loss of Ia-like determinant+, OKT 6+ dentritic epithelial cells in all leukemic patients, as well as in patients with aplastic anemia with or without GvHD suggested damage of Langerhans cells due to the previous radiotherapy and/or specific immunological destruction. In patients with fatal outcome of GvHD prolonged reduction of these dentritic epithelial cells seemed to be indicative of impaired immune reconstitution or bone marrow dysfunction. Thus immunopathological features of skin GvHR may enable early recognition and prognostic evaluation of this disease possibly allowing more effective therapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Gerontologie + Geriatrie 32 (1999), S. 456-472 
    ISSN: 0044-281X
    Keywords: Schlüsselwörter Alter – psychologische Gerontologie – Kompetenz – Selbständigkeit – Gesundheit – Krankheit – Sterben – Tod ; Key words Old age – Psychological gerontology – competence – independence – health – illness – death – dying
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In this four-part review article, an update covering the gero-psychological research since 1988 in German speaking countries is given as follows: Cognitive development in old age (part I), personality development in old age (part II), social relations in old age (part III), age-related tasks, burdens, and border situations (part IV). In part IV of the update presented in this issue, research contributing to a competence perspective of old age and aging is summarized under four main headings: (1) Independence, everyday life, and everyday competence; (2) aging in spatial, physical, and technical environments; (3) health and coping with illness; (4) coping with death and dying. The article ends with a general discussion considering as well the findings of our survey addressing gerontologists from German speaking countries.
    Notes: Zusammenfassung In diesem vierteiligen Übersichtsartikel wird über die gerontopsychologische Forschung in deutschsprachigen Ländern seit 1988 wie folgt berichtet: Kognitive Entwicklung im Alter (Teil I), Persönlichkeitsentwicklung (Teil II), soziale Beziehungen im Alter (Teil III) und Aufgaben, Belastungen und Grenzsituationen (Teil IV). In Teil IV der folgenden Übersichtsarbeit werden Arbeiten behandelt, die in unterschiedlicher Weise zu einer Kompetenzperspektive von Alter und Altern beitragen. Es handelt sich im einzelnen um die Forschungsthemen (1) Selbständigkeit, Alltagsgestaltung und Alltagskompetenz im Alter, (2) Altern in räumlich-sozialen-technischen Umwelten, (3) Gesundheit und Umgangsformen mit Krankheit als Ressourcen für Kompetenz sowie (4) Umgang mit der Grenzerfahrung von Sterben und Tod. Am Ende steht eine allgemeine Diskussion, wobei auch die Ergebnisse einer von uns durchgeführten Umfrage unter Gerontologinnen und Gerontologen im deutschsprachigen Raum Berücksichtigung finden.
    Type of Medium: Electronic Resource
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