Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 0005-2795
    Keywords: (Parafollicular cell) ; 19 S Thyroglobulin ; 27 S Iodoprotein ; Immunoperoxidase reaction
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 206 (1980), S. 403-415 
    ISSN: 1432-0878
    Keywords: C cell complex ; Dog fetus ; C-thyroglobulin ; Calcitonin ; Immunoperoxidase reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The development of C-cell complexes was investigated in dog fetuses by an immunoperoxidase method with three specific antisera: anti-calcitonin, anti-C-thyroglobulin (C-Tg), and anti-19S thyroglobulin. Ultimobranchial bodies joined with the thyroid anlage and then dispersed into the parenchyma to form large C cell groups. Sparse reaction products of C-Tg initially appeared in C cells with small amounts of cytoplasm. Later at about day 39 of gestation, when the immunoreactivity of calcitonin and 19S thyroglobulin appeared weakly in C cells and follicular cells, C-cell complexes were identified as large cell masses containing numerous undifferentiated cells without no immunoreactivity for any of the antisera. As development proceeded, the undifferentiated cells developed progressively the morphology of C cells. In addition, the undifferentiated cells developed 19S thyroglobulin immunoreactivity, that is, within some of the complexes small clusters of cells filled with material immunoreactive for 19S thyroglobulin. They were not organized into follicles during the fetal period, and were very slow in development. Depending on the degree of development of the undifferentiated cells, several features of the complexes were noted. The present study indicates that not only C cells but also follicular thyroid cells appear to be derived from the ultimobranchial bodies.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-0878
    Keywords: C-cell complex ; Immunoperoxidase reaction ; Hypercalcemia ; Antithyroid drug treatment ; Hypophysectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The C-cell complexes are remnants of ultimobranchial bodies retaining fetal characteristics. They contain C cells in various stages of differentiation, primordial follicles with small lacunae, follicular cell masses not yet forming follicles, and undifferentiated epithelial cells. By immunoperoxidase method using specific anti-calcitonin, anti-C-thyroglobulin and anti-19S thyroglobulin sera, the responses of C-cell complexes to hypercalcemia, thiourea, hypophysectomy and hypercalcemia after hypophysectomy were investigated systematically. These experimental conditions induced rapid differentiation and increased numbers of cells in the complexes. After chronic hypercalcemia, most of the complexes were occupied by mature C cells. The C cells in complexes similar to the cells in thyroid parenchyma presented increased mitotic activity, enlarged cell bodies and a marked decrease in materials immunoreactive for calcitonin and C-thyroglobulin. After prolonged administration of thiourea, follicular cell masses and small follicles, which underwent conspicuous hyperplasia and hypertrophy, markedly increased in the complexes and exceeded C cells in number. Typical undifferentiated cells were not recognized after hypercalcemia and treatment with thiourea, though they were unaffected by hypophysectomy. It is considered that undifferentiated cells develop into C cells after hypercalcemia and into follicular cells after treatment with thiourea; that is, undifferentiated cells seem to be the common precursor cell for both C cells and follicular cells.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...