Bibliothek

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • Cyphomyrmex minutus  (1)
  • Immunophilin  (1)
  • symbiosis  (1)
Datenquelle
Materialart
Erscheinungszeitraum
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Structural studies on FK-506, cyclosporin A and their immunophilin complexes (1994)
    Springer
    Perspectives in drug discovery and design 2 (1994), S. 127-144 
    Details
    ISSN: 1573-9023
    Schlagwort(e): Immunophilin ; FK-506 binding protein ; FKBP ; Cyclophilin ; X-ray structure ; Active site-ligand interactions ; Calcineurin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The immunosuppressants FK-506 and cyclosporin A (CsA), along with their macromolecular receptors FKBP12 and cyclophilin A (CyPA), have become important targets for structure-based drug design. In the last few years X-ray diffraction and NMR spectroscopy have combined to provide high-resolution structures of FK-506, CyA, FKBP12, CyPA, FKBP12-FK-506, CyPA-CyA, and other complexes. This review summarizes these structural studies and some of their implications. Because the immunosuppressant-immunophilin complex forms a composite binding surface that interacts with yet another protein, structure-based drug design in this area is unusually challenging.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02171740
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Antifungal Diketopiperazines from Symbiotic Fungus of Fungus-Growing Ant Cyphomyrmex minutus (1999)
    Springer
    Journal of chemical ecology 25 (1999), S. 935-941 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Antifungal ; diketopiperazine ; Cyphomyrmex minutus ; fungus-growing ant ; symbiosis ; Tyridiomyces formicarum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The attine fungus Tyridiomyces formicarum, the symbiont of the fungus-growing ant Cyphomyrmex minutus, produces several antifungal diketopiperazines. This represents the first identification of antifungal compounds from an attine symbiont and contradicts previous suggestions that attine fungi do not produce metabolites with antifungal activity. T. formicarum probably produces antifungal compounds in defense (1) against other fungi that invade the gardens and escape the weeding activity of the ants, or (2) against ant-pathogenic fungi that could harm the host ants. Fungi cultivated by fungus-growing ants may represent a rich source of additional bioactive metabolites.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1020861221126
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...