ISSN:
1573-1111
Keywords:
hyodeoxycholic acid
;
2-Hydroxypropyl-β-cyclodextrin
;
Inclusion complex
;
Solubility studies
;
13C- and 1H-NMR spectroscopy
;
Circular dichroism
;
IR spectroscopy
;
X-ray diffractometry
;
Thermal analysis
;
Dissolution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Hyodeoxycholic acid (HDCA) isa 6-α dihydroxylated natural bile acid capable ofpreventing gallstone formation by reducing the bilecholesterol saturation. However, any attempt to enrichthe bile acid pool with HDCA have failed owing to thepoor solubility of the molecule. To resolve thebioavailability problems, the complexation of HDCAinto the HPβCD cavity was studied in solution(solubility methods, 13C- and 1H-NMRspectroscopy and circular dichroism) and in the solidstate (IR spectroscopy, X-ray diffractometry andthermal analysis). According to the results, the HDCAinclusion took place with 1 : 1 stoichiometry. Theinfluence of different preparation methods of thesolid complex was evaluated for its potential use inappropriate pharmaceutical formulations to improve thebioavailability of HDCA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008162912495
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