ISSN:
1432-0584
Keywords:
Idiopathic thrombocytopenic purpura
;
High-dose immunoglobulin therapy (IVIg)
;
Indium-labeled platelets
;
In vivo scintigraphy
;
Prediction of IVIg effect
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The correlation between the response to high-dose immunoglobulin therapy (IVIg) and the sequestration pattern of Indium-labeled platelets (In-PLT) in the body was studied in 9 patients with chronic idiopathic thrombocytopenic purpura (ITP). Patients that has prominent platelet sequestration in the spleen responded to IVIg. In these patients, splenic sequestration decreased by 20–30% after IVIg without significant changes in hepatic sequestration. This finding suggests that the blocking of splenic Fc receptors with immunoglobulin minimized the destruction of sensitized platelets. However, patients who had almost equal platelet sequestration in the liver and spleen did not respond to IVIg. In these patients, hepatic sequestration decreased after IVIg, whereas splenic sequestration increased. Thus, it appears that estimating the platelet sequestration pattern using In-PLT is useful for predicting the effects of IVIg.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320255
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