ISSN:
1741-0444
Keywords:
Conductivity dilution method
;
Extravascular lung thermal volume
;
Indocyanine green dye
;
Mean transit time
;
Nondiffusible indicator
;
Sodium chloride docyanine green dye
;
Mean transit time
;
Nondiffusible indicator
;
Sodium chloride
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract The authors examined the usefulness of sodium chloride as a nondiffusible indicator during the first passage through dogs' lungs, before and after increased-permeability pulmonary oedema produced by an intravenous injection of alloxan. With an injection of a mixture of ice-cold 3 per cent sodium chloride and indocyanine green dye (a nondiffusible reference indicator), the authors simultaneously recorded three dilution curves from the aortic root: dye dilution, thermal and blood electrical conductivity dilution curves in six dogs. The mean transit time of sodium chloride in the conductivity dilution curve was significantly different from, but fairly equal to, that of indocyanine green dye (6·2±1·4 s (mean±SD) against 6·5±1·4s(p〈0.01) in the baseline period, and 7·6±1·9 s against 8·4±2·1 s (p〈0·01) in the oedema period, respectively). The calculated extravascular lung thermal volume with the thermal and conductivity dilution method (Y, ml kg−1) correlated well with the gravimetrically determined extravascular lung mass in a total of 12 dogs, including six other dogs without intervention (x, g kg−1) (y=0·72x±3·03, r=0·96). The authors conclude that sodium chloride is useful as a nondiffusible indicator in the first passage through the lungs, and that the thermal and conductivity dilution method is also useful for measuring extravascular lung water mass.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02446652
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