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  • 1
    Digitale Medien
    Digitale Medien
    Oberflächenbehandlung von Kohlenstoffasern und mechanische Eigenschaften von Laminaten (1985)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 16 (1985), S. 232-238 
    Details
    ISSN: 0933-5137
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Zusätzliches Material: 18 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mawe.19850160705
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  • 2
    Digitale Medien
    Digitale Medien
    Oberflächenbehandlung von Kohlenstoffasern und mechanische Eigenschaften von Laminaten (1985)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 16 (1985), S. 215-222 
    Details
    ISSN: 0933-5137
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Beschreibung / Inhaltsverzeichnis: Surface Treatment of Carbon Fibres and Resulting Composite PropertiesIn composites carbon fibres are used as reinforcing fibres with thermosetting and thermoplastic resins as martices. These carbon fibres differ strong in their micro-structure and therefrom in fibre properties. To achieve sufficiant composite properties special carbon fibre surface treatment methods are necessary. This paper describes a systematic study on oxidative surface treatment of carbon fibres by wet-, dry- and anodic oxidation. Further investigations by matrix variation show us the influence of matrix strength on the mechanical composite properties. Finally it is shown that in case of impact load composite fracture behaviour is controlled only by the fibre itself.
    Notizen: In neuester Zeit finden Kohlenstoffasern zunehmend Verwendung als Verstärkungsfasern in Verbundkörpern mit thermoduren und thermoplastischen Matrixsystemen. Aufgrund des strukturellen Feinaufbaus unterscheiden sich deren mechanischen Eigenschaften. Um die Fasereigenschaften jedoch im Verbund gezielt ausnutzen zu können, müssen spezielle Methoden der Oberflächenaktivierung angewandt werden. Im vorliegenden Fall werden naßchemische, thermische und elektrochemische Oxidation von Kohlenstoffasern vorgestellt, die Auswirkungen auf Faser- und Verbundeigenschaften untersucht und vergleichend diskutiert. Weiterführende Studien durch Matrixvariation verdeutlichen deren Bedeutung bei der Verbundkörperherstellung. Endlich wird gezeigt, daß bei schneller Lastaufgabe die Eigenschaft der Verstärkungsfaser völlig die Verbundeigenschaft kontrolliert.
    Zusätzliches Material: 21 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mawe.19850160606
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  • 3
    Digitale Medien
    Digitale Medien
    Selective quantification of ambroxol in human plasma by HPLC (1986)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 9 (1986), S. 561-565 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Liquid chromatography, HPLC ; Pharmacokinetics ; Quantification in human plasma ; Bronchosecretolyticum ; Separation from metabolites ; Ambroxol ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The bronchosecretolytic drug ambroxol can be reliably quantified in human plasma by high performance liquid chromatography. Plasma is buffered alkaline, extracted with ether, and the organic solvent back-extracted with diluted acid. An automatically sampled aliquot is separated by reversed phase HPLC; the analyte is well separated from two metabolites that interfered strongly in earlier methods. UV detection at 230 nm enables a lower limit of quantitation of 5 ng/ml. Internal standardization with propranolol allows accurate and precise quantification. Evaluation of the optimized combination of mobile and stationary phase is described, and application of the method to experimental and clinical pharmacokinetic studies is illustrated.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240091004
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  • 4
    Digitale Medien
    Digitale Medien
    Femtogram level quantitative determination of nitroglycerin and metabolites in human plasma by GC-MS negative ion chemical ionization, single ion monitoring (1983)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 6 (1983), S. 68-71 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Gas chromatography/mass spectrometry ; Capillary, fused silica ; Negative ion ; Femtogram sensitivity ; Nitroglycerin ; Organic nitrates ; Dinitroglycerin ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Recent developments in the use of negative ion detection in GC-MS have indicated the potential for highly sensitive analyses for certain compounds. This paper describes the application of the techniques to the assay of Nitroglycerin and its metabolites yielding sensitivity to two femtograms. Because of the low levels of nitroglycerin in biological media such sensitivity is highly desirable if not essential for meaningful measurements. In addition to sensitivity the method is shown to yield extremely good selectivity contributing further to the credibility of quantitative results.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240060204
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  • 5
    Digitale Medien
    Digitale Medien
    Determination of glibenclamide in human serum by HPLC (1986)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 9 (1986), S. 102-105 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Liquid chromatography, HPLC ; Pharmacokinetics ; Quantitation in human serum ; Antidiabeticum ; Glibenclamide ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The antidiabetic drug glibenclamide can be reliably quantitated in human serum with high performance liquid chromatography. The serum is buffered and extracted with toluene. The organic solvent is evaporated, the residue dissolved in the mobile phase and an aliquot sampled automatically and chromatographed. UV-detection at 229 m allows a lower limit of quantitation of 5 ng/ml. Precise handling of exact volumes facilitates external calibration. Statistical data for imprecision and inaccuracy are given and illustrate reliable quantification. Application of the method to experimental and clinical pharmacokinetic studies with specific problems is illustrated.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240090209
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  • 6
    Digitale Medien
    Digitale Medien
    Determination of bile acids and lysolecithin in artificial and natural gastric juice by HPLC for characterization of antacida (1985)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 8 (1985), S. 831-837 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Liquid chromatography, HPLC ; Characterization of antacida ; Gastric juice ; Bile acids ; Lysolecithin ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Work-up procedures and HPLC separation systems for determination of taurocholic, glycocholic, chenodeoxycholic, and cholic acids and lysolecithin in artificial and natural gastric juice are described. These compounds are used for testing the binding capacity of antacida to the individual analytes. Work-up is simple, no extraction or filtration being required. The optimized combinations of stationary and mobile phases allow selective and sensitive determination of the respective bile acids in gastric juice. For optimization, the capacity factors of two related bile acids were evaluated for numerous commercial stationary phases. The mechanism of retention is different for free and conjugated bile acids. Special aspects of routine analysis are discussed.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240081205
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  • 7
    Digitale Medien
    Digitale Medien
    Automated determination of nifedipine in human plasma by capillary gas chromatography with electron capture detection (1986)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 9 (1986), S. 397-399 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Gas chromatography, GC ; Capillary columns ; Nifedipine ; Determination in human plasma ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A rapid, sensitive, and reliable method for the determination of nifedipine in human plasma is described. Using a single-step solvent extraction and capillary gas chromatography combined with electron capture detection, an assay sensitivity of 2 ng/ml is achieved routinely using 0.5 ml of plasma. Intact nifedipine is quantitated and separated from its nitroso- and nitropyridine-derivatives. The suitability of the assay for pharmacokinetic studies is illustrated.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240090706
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  • 8
    Digitale Medien
    Digitale Medien
    Determination of acetylsalicylic acid and salicylic acid in blood and plasma by HPLC (1983)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 6 (1983), S. 655-660 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Liquid chromatography, HPLC ; Influence of sample solvent on peak shape ; Influence of trace ions on peak shape ; Acetylsalicylic acid ; Salicylic acid ; Determination in blood and plasma ; Suppression of the enzymatic degradation of acetylsalicylic acid ; Sample preparation and extraction ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A method is described for the determination of acetylsalicylic acid and salicylic acid in human whole blood and plasma which uses liquid chromatography with UV detection. The enzymatic degradation of acetylsalicyclic acid in blood and plasma is examined. Addition of potassium fluoride as enzyme inhibitor and deep freezing after plasma preparation allows storage of plasma for one week. A mixture of acetonitrile and diluted acetic acid as mobile phase give the best peak shape. Traces of iron lead to slight peak broadening; addition of EDTA results in excessive tailing. The detection limit for acetylsalicylic acid and salicylic acid is about 250 ng/ml for a 1.0 ml primary sample. The method is sensitive enough for the monitoring of both drugs in bioavailability studies.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240061204
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  • 9
    Digitale Medien
    Digitale Medien
    High performance liquid chromatographic determination of metoclopramide in plasma and urine and its application to biopharmaceutical investigations (1987)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 10 (1987), S. 659-664 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Liquid chromatography, HPLC ; Quantification in human plasma and urine ; Pharmacokinetics ; Subanogram sensitivity ; Metoclopramide ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: An optimized HPLC method for the quantification of metoclopramide (MCP) in human plasma and urine is described. MCP and internal standard are extracted from alkalinized substrate into diethyl ether and back-extracted into dilute acid. The analytes are separated with a ternary mobile phase at cyanopropyl-silica and detected at 312 nm (UV detection). The lower limit of quantification is 0.5 ng/ml in plasma and 50 ng/ml in urine. Optimization of extraction, chromatography, and detection is discussed. The method is selective to numerous common drug substances with excellent accuracy and precision data. After validation, the method is applied to the samples of a pharmacokinetic study. Pharmacokinetic parameters indicate the need for a sophisticated method as tool for optimization of metoclopramide formulations.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240101208
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  • 10
    Digitale Medien
    Digitale Medien
    Improved automated simultaneous determination of isosorbide dinitrate and its metabolites in plasma by capillary column gas chromatography (1984)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 7 (1984), S. 58-65 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Gas chromatography/ECD ; Capillary, fused silica ; Isosorbide dinitrate ; Isosorbide-/isomannide-/isoidide-mononitrates ; Human plasma ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: An automated specific and sensitive method for the simultaneous determination of isosorbide dinitrate and its metabolites isosorbide-2-mononitrate, isosorbide-5-mononitrate, isomannide mononitrate, and isoidide mononitrate at concentrations down to 0.5, 1, 3, 2, and 2 ng/ml, respectively, in human plasma is described. The procedure involves the extraction of the drug and its metabolites together with their internal standards isomannide dinitrate and o-nitrobenzyl alcohol from plasma with dicholromethane.The analysis is carried out by fused silica capillary gas chromatography using a 63Ni-electron capture detector. The method is applied to the pharmacokinetics of isosorbide dinitrate in humans.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240070202
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