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Digitale Medien

Altered distribution of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-d-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy (1996)

Blümcke, I. ; Beck, Heinz ; Scheffler, Björn ; [weitere]

Springer

Acta neuropathologica 92 (1996), S. 576-587

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ISSN: 1432-0533

Schlagwort(e): Key words Excitatory amino acids ; Therapy-refractory epilepsy ; Ammon’s horn sclerosis ; Quantitative image analysis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract In patients with therapy-refractory temporal lobe epilepsy (TLE), alterations of glutamate receptors have been proposed as a mechanism for enhanced excitability. Using commercially available monoclonal antibodies specific for the N-methyl-d-aspartate (NMDA) receptor subunit NMDAR1 and for the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4), we have examined the distribution of these polypeptides in human hippocampal tissue that was surgically removed from patients with intractable TLE. Surgical specimens were classified according to the presence of Ammon’s horn sclerosis (AHS) or a focal lesion in the temporal lobe. Cell counts and a densitometric analysis of the immunoreactivity patterns were carried out for all hippocampal subfields. NMDAR1 and GluR2(4) levels were markedly reduced in patients with AHS, primarily in those subfields with substantial neuronal cell loss (in particular CA1, CA4 and CA3), compared to those seen in patients with focal lesions and in control specimens obtained at autopsy. In contrast, the molecular layer of the dentate gyrus (DG-ML) showed significantly higher levels of GluR2(4) immunoreactivity in AHS compared to control tissue, while NMDAR1 showed no significant up-regulation in this sublayer. When the receptor staining intensity was normalized for alterations in neuronal density, no significant alterations could be detected except for an increase in GluR2(4) in the DG-ML of patients with AHS. These changes may reflect synaptic reorganization observed in the DG-ML of specimens from patients with chronic intractable TLE.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s004010050564

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Digitale Medien

Lüftungseigenschaften von Laborabzügen (Digestorien) (1964)

Beck, Heinz

Weinheim : Wiley-Blackwell

Chemie Ingenieur Technik - CIT 36 (1964), S. 455-460

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ISSN: 0009-286X

Schlagwort(e): Chemistry ; Industrial Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: Es wurden fünf Abluftsysteme von Laborabzügen auf den erforderlichen Luftdurchsatz untersucht. Dabei zeigte sich, daß die Durchlüftung von Abzügen bei nahezu geschlossenem Frontschieber praktisch unabhängig von der Anordnung der Absaugeöffnung ist. Der Einfluß von äußeren Störungen bei geöffnetem Schieber zeigt, daß die abzusaugende Luftmenge nur dann in wirtschaftlich vertretbarer Größe bleibt, wenn man bei nahezu geschlossenem Abzug arbeitet.

Zusätzliches Material: 11 Ill.