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  • Insulin  (2)
  • 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors  (1)
  • 1
    ISSN: 1432-1440
    Keywords: Diabetes mellitus ; Enteral formula ; Fructose ; Insulin ; Xylitol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To verify the benofit of nonglucose carbohydrates and fiber in enteral formula diets we studied the postprandial metabolism of eight healthy subjects after the intake of two helpings (25 g carbohydrates each) of five commonly used enteral formulas over 4 h. There were no significant differences in postprandial concentrations of blood glucose among the formulas. The area under the curve of postprandial insulin values, however, was significantly smaller after consumption of the fructose-containing formula (1948±285 μU min ml−1, P〈0.05) than after fiber-free (3222 ±678 μU min ml−1) or two fiber-containing products (2664±326 μU min ml−1, P〈0.05; and 3040±708 μU min ml−1, P〈0.05). The insulin area of the xylitol-containing formula (2307±364 μU min ml−1) was significantly smaller compared to the fiber-free product (P〈0.05). In addition, we found the postprandial increase in triglycerides to be significantly higher after the xylitol-containing formula (from 0.93±0.14 to 1.25±0.22 mmol/1) than after the fiber-free product (from 0.82±0.13 to 0.97±0.16 mmol/1, P〈0.05) or the two fiber-containing products (from 0.88±0.16 to 0.96±0.18 mmol/1, P〈0.05; and from 0.80±0.08 to 0.95±0.10 mmol/l, P〈0.05). We conclude that a patient with type 11 diabetes may benefit from replacing glucose and glucose-equivalent carbohydrates with fructose or xylitol.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Regulatory Peptides 29 (1990), S. 257-266 
    ISSN: 0167-0115
    Keywords: Adipose tissue ; Insulin ; Lipolytic activity ; Rabbit
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Keywords: Low-density lipoprotein apheresis ; Immunoadsorption ; 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors ; Combined therapy ; Familial hypercholesterolemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To establish whether additional therapy with 3-hydroxy-3-methylglutaryl (HMG) coenzyme A (CoA) reductase inhibitors enhances the low-density lipoprotein (LDL) cholesterol lowering effect of LDL apheresis with immunoadsorption in the treatment of patients with familial heterozygous hypercholesterolemia and coronary artery disease we studied eight patients initially on immunoadsorption therapy alone for 3 years. The adding of HMG CoA reductase inhibitors decreased pretreatment LDL cholesterol from 6.76±0.98 to 4.97±0.98 mmol/l and posttreatment LDL cholesterol from 2.33±0.80 to 1.94±0.67 mmol/l and increased pre- and posttreatment high-density lipoprotein (HDL) cholesterol by 0.08 and 0.13 mmol/l respectively. The LDL/HDL ratio was reduced from 4.0 to 2.8 (prior to any therapy the ratio was 13.4). The increase in LDL cholesterol between weekly treatments was less steep under the combined therapy. At the same time the treated plasma volume during LDL apheresis could be decreased from 5070±960 to 4370±1200 1200 ml. We conclude that in patients with severe familial heterozygous hypercholesterolemia LDL apheresis should be combined with HMG CoA reductase inhibitors.
    Type of Medium: Electronic Resource
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