Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Tyrosine kinase activity of insulin receptors from an insulin-resistant patient with leprechaunism (1987)
    Springer
    Diabetologia 30 (1987), S. 631-637 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; tyrosine kinase ; insulin resistance ; anti-receptor antibodies ; leprechaunism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Defects in insulin receptor function can impair the response of target cells to insulin. Previously we have described an insulin resistant patient (leprechaun/Ark−1) with qualitative abnormalities in insulin binding suggestive of a structural defect in her insulin receptors. In the present work, we have studied the tyrosine kinase activity associated with insulin receptors from cultured Epstein-Barr virus-transformed lymphocytes. In studies of insulin receptors from leprechaun/Ark−1, we observed that both the magnitude and the dose-dependency of insulin's effect to stimulate the tyrosine kinase activity were normal. This suggests that the defect causing this patient's insulin resistance is independent of the receptor-associated tyrosine kinase. In the course of these studies, we noted that an anti-receptor antiserum (B−d) had a markedly decreased ability to immunoprecipitate insulin receptors from leprechaun/Ark−1. This observation further supports our previous conclusion that the insulin receptor from leprechaun/Ark−1 is abnormal in structure. Moreover, it emphasizes the importance of choosing anti-receptor antisera which are equally effective at immunoprecipitating receptors from both patients and normal subjects when the anti-receptor antisera are employed as reagents in investigations of receptors from insulin-resistant patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277320
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Occult spinal dysraphism: neuroradiological study (1990)
    Springer
    Neuroradiology 31 (1990), S. 512-522 
    Details
    ISSN: 1432-1920
    Keywords: Occult spinal dysraphism ; Lipoma ; Tethered cord ; Spinal cord ; Caudal regression syndrome ; Developmental mass lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present a retrospective study of occult spinal dysraphism in 47 children aged 0 to 14 years, all studied with plain X-rays, 60% with CT and myelo-CT, and 40% with MR. We consider the classification and grading of these malformations, clinical, neuroradiological patterns, and indications for surgery. In the light of our findings and of the published data MR emerges as the key investigation. Only in a few cases of great anatomical complexity is it now necessary to perform CT and myelo-CT as well. A case in point is when the conus and thickened filum terminale are inextricably bound together and can no longer be considered separate structures. We propose the term “neurofibrous structure” to define the conus-thickened-filum-terminale unit when these structure are no longer distinguishable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340133
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification (2000)
    Springer
    Neuroradiology 42 (2000), S. 471-491 
    Details
    ISSN: 1432-1920
    Keywords: Key words Spine ; dysraphism ; Spinal cord ; tethered ; Spina bifida magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our purpose was to review the neuroradiological features of spinal dysraphism and to correlate them with clinical findings and up-to-date embryological theory. We also aimed to formulate a working classification which might prove useful in clinical practice. We reviewed series of 986 children referred to our Spina Bifida Centre in the past 24 years. There were 353 children with open spinal (OSD) and 633 with closed (skin-covered) spinal (CSD) dysraphism. By far the most common open abnormality was myelomeningocele, and all patients with OSD had a Chiari II malformation. CSD was categorised clinically, depending on the presence of a subcutaneous mass in the back. CSD with a mass mainly consisted of lipomas with dural defects and meningoceles, and accounted for 18.8 % of CSD. CSD without a mass were simple (tight filum terminale, intradural lipoma) or complex (split cord malformations, caudal regression). Our suggested classification is easy to use and to remember and takes into account clinical and MRI features; we have found it useful and reliable when making a preoperative neuroradiological diagnosis in clinical practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340000325
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...