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Interferon receptors and their role in interferon action (1989)

Grossberg, S. E. ; Taylor, J. L. ; Kushnaryov, V. M.

Springer

Cellular and molecular life sciences 45 (1989), S. 508-513

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ISSN: 1420-9071

Keywords: Interferons ; cell receptors ; nuclear receptors ; membrane effects

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Interferon (IFN)_proteins interact with cells through specific cell surface receptors, some of which have been purified and cloned. The alpha-IFNs and beta-IFN bind to a common receptor (type I), whereas gamma-IFN binds to a separate receptor (type II). Both types of high-affinity receptors have been demonstrated on a variety of different kinds of cells but in relatively low numbers (102–104/cell). The relationship between IFN binding to receptors and the ways in which IFNs may affect cellular physiology and gene expression is discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01990499

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