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  • 1
    Electronic Resource
    Electronic Resource
    Elimination and pharmacological effects following single oral doses of 50 and 75 mg of amitriptyline in man (1983)
    Springer
    European archives of psychiatry and clinical neuroscience 233 (1983), S. 449-455 
    Details
    ISSN: 1433-8491
    Keywords: Amitriptyline ; Nortriptyline ; Hydroxylated metabolites ; Linear disposition ; Interindividual differences ; Pharmacological effects ; Psychomotor tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a companion paper we described the disposition of a 75 mg single dose of amitriptyline in normal volunteers who were phenotyped as extensive or poor metabolizers of debrisoquine and bufuralol, and had a four-fold range in the oral clearance of the antidepressant, 50 mg of amitriptyline was also administered to the same volunteers. This paper compares the results after both doses and suggests that the disposition of amitriptyline is linear even in subjects with a low oral clearance. There was no relation between the pharmacokinetic data and the intensity of sedation or of psychomotor impairment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00342785
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man (1982)
    Springer
    European archives of psychiatry and clinical neuroscience 232 (1982), S. 215-222 
    Details
    ISSN: 1433-8491
    Keywords: Amitriptyline ; Nortriptyline ; Hydroxylated metabolites ; Oxidation polymorphism ; Hydroxylation polymorphism ; Pharmacogenetics ; Interindividual differences ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have measured the metabolites (demethylated and hydroxylated) of amitriptyline in a group of seven normal volunteers. They were phenotyped as extensive or poor metabolizers using debrisoquine and bufuralol. The results demonstrate that the oxidative metabolism (aliphatic hydroxylation) of amitriptyline is under the same genetic control as that of debrisoquine and bufuralol. However, phenotypic polymorphism cannot be used to predict amitriptyline blood concentration after a single oral dose, since the principal metabolic pathway of amitriptyline is demethylation and not aliphatic hydroxylation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02141782
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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