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  • 1
    Electronic Resource
    Electronic Resource
    Intestinal metaplasia and adenocarcinoma induced in the stomach of rats by N-propyl-N′-nitro-N-nitrosoguanidine (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 201-206 
    Details
    ISSN: 1432-1335
    Keywords: Intestinal metaplasia ; Gastric carcinoma N-Propyl-N′-nitro-N-nitrosoguanidine ; Wistar rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary PNNG, the propyl derivative of MNNG, was administered to Wistar rats at a concentration of 59.5 μg/ml in the drinking water for 4, 8, and 12 months and the rats were killed in the 15th month. Intestinal metaplasia was induced in the glandular stomachs of 25%, 75%, and 83% of the rats treated with PNNG for 4, 8, and 12 months, respectively. Metaplastic glands were found in the pyloric region, especially near the pyloric ring. These glands contained goblet cells and columnar cells with striated borders. No tumors were found in the stomach of rats after 4-months treatment, but adenomas were found after 8-months treatment, and both adenomas and adenocarcinomas after 12-months treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422498
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sequential studies on the histopathogenesis of gastric carcinoma in rats by a weak gastric carcinogen, N-propyl-N′-nitro-N-nitrosoguanidine (1980)
    Springer
    Journal of cancer research and clinical oncology 98 (1980), S. 153-163 
    Details
    ISSN: 1432-1335
    Keywords: Gastric carcinoma ; Intestinal metaplasia ; N-Propyl-N′-nitro-N-nitrosoguanidine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sequential studies were made on the histopathologic changes in the glandular stomach of rats induced by a weak carcinogen, N-propyl-N′-nitro-N-nitrosoguanidine (PNNG). Fiftyfour rats were given 100 μg/ml of PNNG in their drinking water for 44 weeks, and then normal tap water until the end of the experiment. Rats were killed at intervals between week 1 and week 88. No marked atrophy or ulceration of the mucosa was found between week 1 and the end of the experiment. Focal intestinal metaplasia was found in week 19 and its incidence increased during the experiment. Adenocarcinoma in situ with extreme cellular atypia was found in mucosa with a normal appearance in week 67. An adenocarcinoma invading the submucosa was found in week 69, and one invading the serosa in week 88. All these pathological lesions were found on the anal side of the pyloric region. No pathologic changes were found in the fundic region. The sequential changes of the mucosa of the glandular stomach induced by this weak gastric carcinogen, PNNG, were very different from those induced by the potent gastric carcinogen, N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Gastric carcinoma induced by PNNG seems to be more similar to human gastric cancer than that induced by MNNG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405959
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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