ISSN:
1433-0350
Keywords:
Infancy
;
Intracranial tumour
;
CT scan
;
Radiotherapy
;
Chemotherapy
;
Long-term outcome
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Records of 92 children were reviewed who, in the first 18 months of life had an intracranial tumour, and who were registered with the Manchester Children's Tumour Registry during the 34-year period from 1953 to 1987. The incidence of intracranial tumour was 1 in 25000 live births, and 85% of the tumours were malignant. The introduction of computed tomography (CT) in the region in 1976 improved the diagnostic accuracy and led to early diagnosis. This also coincided with refined radiotherapy and improved chemotherapy. The surgical attitude became more aggressive, and with early treatment, mortality was reduced, though the 1-month operative mortality still remains high at 15%. All survivors were available for follow-up. All children with axial tumours died within 9 years. Long-term follow-up did not suggest significant improvement in the overall survival or in the quality of life, though there was a significant improvement in the 5-year survival rate with modern management.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00298278
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