ISSN:
0947-3440
Schlagwort(e):
Prins reaction
;
Intramolecular cyclization
;
1-Azabicyclo[3.3.1]nonadienes
;
Diastereoselectivity
;
Dopamine uptake inhibitors
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Intramolecular cyclization reactions were performed with 1-(3-oxo-2-phenylbutyl)-1,2,5,6-tetrahydropyridine derivatives 6a-h in sulfuric acid to give 3,6-diphenyl-substituted 1-aza-bicyclo[3.3.1]nonadienes 9. The intermediate carbinols 7a-f and 8b, c could be isolated. Carrying out the reaction in methanesulfonic acid stereoselectivity was found in the formation of carbinols with preferential production of derivatives 7. Some of the compounds 9 show remarkable dopamine uptake inhibition.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/jlac.1995199511287
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