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  • 1
    Electronic Resource
    Electronic Resource
    Stable carbon isotope ratios in Asian elephant collagen: implications for dietary studies (1992)
    Springer
    Oecologia 91 (1992), S. 536-539 
    Details
    ISSN: 1432-1939
    Keywords: Stable carbon isotopes ; Collagen ; Diet ; Asian elephant ; Elephas maximus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Stable carbon isotope ratios in bone collagen have been used in a variety of dietary studies in modern and fossil animals, including humans. Inherent in the stable isotope technique is the assumption that the isotopic signature is a reflection of the diet and is persistent in collagen because this is a relatively inert protein. Carbon isotope analyses of bones from a southern Indian population of Asian elephant (Elephas maximus), a long-lived mammal that alternates seasonally between a predominantly C3 (browse) and C4 (grass) plant diet, showed two patterns that have important implications for dietary interpretation based on isotopic studies. Relative to the quantity of the two plant types consumed on average, the δ13C signal in collagen indicated that more carbon was incorporated from C3 plants, possibly due to their higher protein contribution. There was a much greater variance in δ13C values of collagen in sub-adult (range -10.5‰ to-22.7‰, variance=14.51) compared to adult animals (range -16.0‰ to -20.3‰, variance=1.85) pointing to high collagen turnover rates and non-persistent isotopic signatures in younger, growing animals. It thus seems important to correct for any significant relative differences in nutritive value of food types and also consider the age of an animal before drawing definite conclusions about its diet from isotope ratios.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00650328
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  • 2
    Electronic Resource
    Electronic Resource
    Simultaneous Regulation of Hemodynamic and Anesthetic States: A Simulation Study (2000)
    Springer
    Annals of biomedical engineering 28 (2000), S. 71-84 
    Details
    ISSN: 1573-9686
    Keywords: Biomedical control systems ; Predictive control ; Physiological models ; Intravenous anesthesia ; Propofol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract A model predictive control strategy to simultaneously regulate hemodynamic and anesthetic variables in critical care patients is presented. A nonlinear canine circulatory model, which has been used to study the effect of inotropic and vasoactive drugs on hemodynamic variables, has been extended to include propofol pharmacokinetics and pharmacodynamics. Propofol blood concentration is used as a measure for depth of anesthesia. The simulation model is used to design and test the control strategy. The optimization-based model predictive control strategy assures that constraints imposed on the drug infusion rates are met. The physician always remains “in the loop” and serves as the “primary controller” by making propofol blood concentration setpoint changes based on observations about anesthetic depth. Results are shown for three simulated cases: (i) congestive heart failure, (ii) postcoronary artery bypass, and (iii) acute changes in hemodynamic variables. © 2000 Biomedical Engineering Society. PAC00: 8719Uv, 8710+e, 8780-y
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1114/1.255
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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