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  • 1
    Electronic Resource
    Electronic Resource
    Ischemic stress induces deposition of amyloid β immunoreactivity in human brain (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 461-466 
    Details
    ISSN: 1432-0533
    Keywords: Key words Amyloid β protein ; Ischemia ; Alzheimer's disease ; Histoblot
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The histoblot immunostaining technique for locating and characterizing amyloidogenic proteins was used to obtain information about the relationship of cerebral ischemia/hypoxia to the accumulation of amyloid β protein (Aβ). We investigated brains of 131 subjects (ages 25–94 years, mean 72 years). Three distribution patterns of Aβ immunoreactivity were identified: (1) colocalization with diffuse and neuritic plaques of Alzheimer's disease (AD) and aging; (2) diffuse punctate deposits in the cerebral cortex in association with small vessel cerebral vascular disease; and (3) cerebral cortical accumulation localized to arterial boundary zones and other regions susceptible to ischemic/hypoxic injury designated "stress-induced deposits" (SID). SID were not identified in tissue sections by immunohistochemical, Congo red or Bielschowsky silver techniques; no histological abnormalities were present in adjacent formalin-fixed tissue sections. SID occurred in subjects with histories of cerebral ischemia, and severe orthostatic hypotension. There was also an association with aging in general and with the incidence of neuritic plaques specifically. These latter findings are consistent with the hypothesis that brain ischemia/hypoxia plays a role in the pathogenesis of AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294806
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Ischemic stress induces deposition of amyloid β immunoreactivity in human brain (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 461-466 
    Details
    ISSN: 1432-0533
    Keywords: Amyloid β protein ; Ischemia ; Alzheimer's disease ; Histoblot
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The histoblot immunostaining technique for locating and characterizing amyloidogenic proteins was used to obtain information about the relationship of cerebral ischemia/hypoxia to the accumulation of amyloid β protein (Aß). We investigated brains of 131 subjects (ages 25–94 years, mean 72 years). Three distribution patterns of Aβ immunoreactivity were identified: (1) colocalization with diffuse and neuritic plaques of Alzheimer's disease (AD) and aging; (2) diffuse punctate deposits in the cerebral cortex in association with small vessel cerebral vascular disease; and (3) cerebral cortical accumulation localized to arterial boundary zones and other regions susceptible to ischemic/hypoxic injury designated “stress-induced deposits” (SID). SID were not identified in tissue sections by immunohistochemical, Congo red or Bielschowsky silver techniques; no histological abnormalities were present in adjacent formalin-fixed tissue sections. SID occurred in subjects with histories of cerebral ischemia, and severe orthostatic hypotension. There was also an association with aging in general and with the incidence of neuritic plaques specifically. These latter findings are consistent with the hypothesis that brain ischemia/hypoxia plays a role in the pathogenesis of AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294806
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of Heat Treatment and Additives on the Photochromic and Mechanical Properties of Sol-Gel Derived Photochromic Coatings Containing Spirooxazine (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 923-926 
    Details
    ISSN: 1573-4846
    Keywords: photochromism ; photochromic coatings ; spirooxazine ; photochromic properties ; mechanical properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The experimental results on the photochromic and mechanical properties of coatings containing 1,3-dihydro-1,3,3-trimethylspiro[2H-indole-2,3′-(3H)-naphth(2,1-b)(1,4) oxazine] (SO) derived from 3-glycidyloxypropyltrimethoxysilane (GPTMS), bisphenol A (BPA) and 1-methylimidazole (MI) by sol-gel processing are presented. It is shown that heat treatment temperature is a conflicting factor to the photochromic intensity (Δ A 0), photostability and abrasion resistance of the photochromic coatings. With increasing densification temperature the matrix rigidity increases leading to a decrease of Δ A 0 and at the same time an enhancement of both abrasion resistance and photostability, the optimum heat treatment temperature is 110°C under our experimental conditions. By the use of certain additives, e.g., fluorosilanes (FAS), not only Δ A 0 but also the photostability and the abrasion resistance of the photochromic coatings have been further improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018384913360
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Enhancement of the Photochromic Performance of Spirooxazine in Sol-Gel Derived Organic-Inorganic Hybrid Matrices by Additives (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 927-929 
    Details
    ISSN: 1573-4846
    Keywords: organic-inorganic hybrids ; sol-gel ; photochromic performance ; spirooxazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Organic-inorganic hybrid materials synthesized via sol-gel processing are excellent solid matrices for photochromic dyes like spirooxazine, and the photochromic performance can be further enhanced by introducing suitable additives. This work describes the effects of additives on the photochromic intensity (Δ A 0), decolouration rate (k) and photostability of spirooxazine in sol-gel derived organic-inorganic hybrid matrices. They include fluoro-alkylsilane (FAS), bisphenol A (BPA) and methyl-imidazole (MI). FAS enhances both Δ A 0 and photostability, but has little effect on k. The higher the content of BPA, the higher the Δ A 0 and the higher the photostability, but the lower the k. The effect of MI on Δ A 0 and k is not so considerable as that of BPA and is a little complicated, while significant improvement in photostability is achieved by the addition of MI at an optimum concentration with the presence of BPA at a higher content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018337030198
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Effect of heat treatment and additives on the photochromic and mechanical properties of sol-gel derived photochromic coatings containing spirooxazine (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 923-926 
    Details
    ISSN: 1573-4846
    Keywords: photochromism ; photochromic coatings ; spirooxazine ; photochromic properties ; mechanical properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The experimental results on the photochromic and mechanical properties of coatings containing 1,3-dihydro-1,3,3-trimethylspiro[2H-indole-2,3′-(3H)-naphth(2,1-b)(1,4) oxazine] (SO) derived from 3-glycidyl-oxypropyltrimethoxysilane (GPTMS), bisphenolA (BPA) and 1-methylimidazole (MI) by sol-gel processing are presented. It is shown that heat treatment temperature is a conflicting factor to the photochromic intensity (ΔA 0), photostability and abrasion resistance of the photochromic coatings. With increasing densification temperature the matrix rigidity increases leading to a decrease of ΔA 0 and at the same time an enhancement of both abrasion resistance and photostability, the optimum heat treatment temperature is 110°C under our experimental conditions. By the use of certain additives, e.g., fluorosilanes (FAS), not only ΔA 0 but also the photostability and the abrasion resistance of the photochromic coatings have been further improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02436961
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Enhancement of the photochromic performance of spirooxazine in sol-gel derived organic-inorganic hybrid matrices by additives (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 927-929 
    Details
    ISSN: 1573-4846
    Keywords: organic-inorganic hybrids ; sol-gel ; photochromic performance ; spirooxazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Organic-inorganic hybrid materials synthesized via sol-gel processing are excellent solid matrices for photochromic dyes like spirooxazine, and the photochromic performance can be further enhanced by introducing suitable additives. This work describes the effects of additives on the photochromic intensity (ΔA 0), decolouration rate (k) and photostability of spirooxazine in sol-gel derived organic-inorganic hybrid matrices. They include fluoroalkylsilane (FAS), bisphenolA (BPA) and methyl-imidazole (MI). FAS enhances both ΔA 0 and photostability, but has little effect onk. The higher the content of BPA, the higher the ΔA 0 and the higher the photostability, but the lower thek. The effect of MI on ΔA 0 andk is not so considerable as that of BPA and is a little complicated, while significant improvement in photostability is achieved by the addition of MI at an optimum concentration with the presence of BPA at a higher content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02436962
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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