ISSN:
1432-2072
Keywords:
Sleep
;
Noradrenaline
;
Debrisoquine
;
Overdose
;
Guanethidine
;
Propranolol
;
β-Blockers
;
Isoprenaline
;
Dexamphetamine
;
Imipramine
;
MAOI
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Debrisoquine in dosage of 20–60 mg continued for up to 10 days caused suppression of human paradoxical sleep and withdrawal rebound, and also increased intra-sleep restlessness. An overdose of debrisoquine 200 mg caused suppression of paradoxical sleep and a rebound of over 2 weeks duration. Guanethidine 20–40 mg for 21 days did not affect paradoxical sleep but increased intra-sleep restlessness and reduced stages 3 + 4 sleep. Propranolol 120 mg had no discernable effect on sleep and did not prevent actions of dexamphetamine sulphate 10 mg nor of imipramine 75 mg. The findings relate to theories of cerebral noradrenaline in the control of sleep mechanisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00572267
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