ISSN:
1432-1076
Keywords:
Key words Excitotocicity
;
Ketamine
;
N-methyl-d-aspartate
;
receptor
;
Strychnine
;
Non ketotic
;
hyperglycinaemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Non-ketotic hyperglycinaemia (NKH) is a severe seizure disorder associated with high glycine levels. Glycine is a major inhibitory neurotransmitter in the CNS, but has also modulating effects at one of the glutamate receptors, the N-methyl- d-aspartate-(NMDA) receptor. Based on this knowledge we treated a female newborn suffering from severe NKH with the NMDA receptor blocker ketamine in association with strychnine and magnesium supplementation. This treatment led to cessation of seizures, reappearance of swallowing and sucking and improved the neurological status. Some pharmacokinetic data of strychnine and ketamine in the infant are given. Conclusion Ketamine in combination with strychnine may be beneficial in non-ketotic hyperglycinaemia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02079070
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