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  • Isradipine  (1)
  • Key Words: Friction, shear heating, fault strength, shear localization, fault gouge.  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 157 (2000), S. 1847-1866 
    ISSN: 1420-9136
    Keywords: Key Words: Friction, shear heating, fault strength, shear localization, fault gouge.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —Heat-flow measurements imply that the San Andreas Fault operates at lower shear stresses than generally predicted from laboratory friction data. This suggests that a dramatic weakening effect or reduced heat production occur during dynamic slip. Numerical studies intimate that grain rolling or localization may cause weakening or reduced heating, however laboratory evidence for these effects are sparse. We directly measure frictional resistance (μ), shear heating and microstructural evolution with accumulated strain in layers of quartz powder sheared at a range of effective stresses (σ n = 5 - 70 MPa) and sliding velocities (V = 0.01 - 10 mm/s). Tests conducted at σ n ≥ 25 MPa show strong evidence for shear localization due to intense grain fracture. In contrast, tests conducted at low effective stress (σ n = 5 MPa) show no preferential fabric development and minimal grain fracture hence we conclude that non-destructive processes such as grain rolling/sliding, distributed throughout the layer, dominate deformation. Temperature measured close to the fault increases systematically with σ n and V, consistent with a one-dimensional heat-flow solution for frictional heating in a finite width layer. Mechanical results indicate stable sliding $(\mu \sim 0.6)$ for all tests, irrespective of deformation regime, and show no evidence for reduced frictional resistance at rapid slip or high effective stresses. Our measurements verify that the heat production equation $(q =\mu \sigma_n V)$ holds regardless of localization state or fracture regime. Thus, for quasistatic velocities (V≤ 10 mm/s) and effective stresses relevant to earthquake rupture, neither grain rolling/sliding or shear localization appear to be a viable mechanism for the dramatic weakening or reduced heating required to explain the heat flow paradox.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 42 (1992), S. 231-233 
    ISSN: 1432-1041
    Keywords: Isradipine ; Haemodialysis ; pharmacokinetics ; dialysability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of isradipine, a calcium-channel blocker, have been studied in eight patients on chronic haemodialysis. A single oral dose of 5 mg was administered on both a non-haemodialysis and a haemodialysis day and the plasma concentrations of isradipine were analyzed. The mean cmax, tmax, AUC, and t1/2 in plasma on the non-haemodialysis day were 5.2 ng·ml−1, 1.4 h, 23.8 ng·h·ml−1, and 3.1 h, respectively. The dialysis clearance of isradipine was negligible (5.0 ml·min−1). The t1/2 values during haemodialysis were not significantly different from those observed during the same period post dose on the non-haemodialysis day. The study demonstrates that supplemental doses of isradipine are not necessary in these patients since isradipine is not significantly removed by haemodialysis.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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