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Electronic Resource

Significance of adrenergic transmission in thermal sweating in man

Ohara, K. ; Morita, Y. ; Okuda, N.

Amsterdam : Elsevier

Journal of Thermal Biology 9 (1984), S. 127-132

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ISSN: 0306-4565

Keywords: Adrenergic sweating ; man ; neuroglandular transmission ; thermal sweating

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0306-4565(84)90051-2

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Etidronate (EHDP) Inhibits Osteoclastic-Bone Resorption, Promotes Apoptosis and Disrupts Actin Rings in Isolate-Mature Osteoclasts (1999)

Hiroi-Furuya, E. ; Kameda, T. ; Hiura, K. ; [et al.]

Springer

Calcified tissue international 64 (1999), S. 219-223

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ISSN: 1432-0827

Keywords: Key words: EHDP — Osteoclast — Apoptosis — Actin rings.

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Physics

Notes: Abstract. Bisphosphonates, therapeutic reagents against tumoral bone diseases (Paget's disease or osteoporosis), are potent inhibitors of bone resorption. The mechanisms by which they directly act on mature osteoclasts remain unclear. Using a recently developed technique for isolation of highly purified mammalian mature osteoclasts, we demonstrated that etidronate [ethane-1-hydroxy-1,1-diphosphonate (EHDP), 1-hydroxy-1,1-ethylidenebisphosphonate], inhibited directly osteoclastic bone-resorbing activity by pit assay. In addition, EHDP also directly induced apoptosis and disrupted actin rings in osteoclasts. The data support previous data on non-purified osteoclasts and results in vivo.