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  • Keratinocyte  (1)
  • Key words: Hepatocellular carcinoma—Transcatheter arterial chemoembolization—Hypercalcemia—Intactparathyroid hormone—Parathyroid hormone-related protein—Venous sampling.  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 21-26 
    Details
    ISSN: 1432-069X
    Keywords: Key words MAGP-1 ; Elastin ; Keratinocyte ; Differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Microfibril-associated glycoprotein (MAGP) is a major structural component of connective tissue microfibrils. We studied the expression of MAGP-1 in cultured human keratinocytes and its modulation during Ca++-induced differentiation. RT-PCR and Western blot assays demonstrated the presence of mRNA and the polypeptide of MAGP-1 in cultured keratinocytes. MAGP-1 mRNA levels in cultured keratinocytes during Ca++-induced differentiation were enhanced eightfold with a concomitant increase in involucrin (a marker of terminal differentiation) mRNA levels. Double immunofluorescence labeling of cultured keratinocytes demonstrated that both anti-MAGP-1 and anti-involucrin antibodies reacted with the identical cells. The population of MAGP-1-producing cells in cultured keratinocytes significantly increased during Ca++-induced differentiation. These results indicate that MAGP-1 expressed by cultured keratinocytes reaches maximum levels at the stage of terminal differentiation in vitro. Double immunostaining of normal human skin with anti-MAGP-1 and anti-elastin antibodies demonstrated the colocalization of MAGP-1-positive and elastin-positive fibers in the superficial and mid-dermis. MAGP-1 produced by keratinocytes may play some functional role in the formation of dermal matrix organization in the dermis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007456
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Intact PTH-producing hepatocellular carcinoma treated by transcatheter arterial embolization (1999)
    Springer
    Abdominal imaging 24 (1999), S. 144-146 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Hepatocellular carcinoma—Transcatheter arterial chemoembolization—Hypercalcemia—Intactparathyroid hormone—Parathyroid hormone-related protein—Venous sampling.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of hepatocellular carcinoma with hypercalcemia. There was no evidence of bone metastasis or increase in parathyroid hormone-related protein. The serum level of intact parathyroid hormone (intact PTH) was very high, and the results of the hepatic venous sampling suggested that the tumor produced intact PTH. Transcatheter arterial chemoembolization effectively controlled the humoral hypercalcemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900463
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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