ISSN:
1432-1971
Keywords:
Key words: Nitric oxide — Congenital heart disease — Pulmonary hypertension — Oxygen — Pulmonary vascular resistance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. The objective of this study was to investigate the efficacy of low-dose nitric oxide (NO). The study used fifteen consecutive Japanese preoperative patients (7 males and 8 females) with congenital heart disease and pulmonary hyptertension (mean pulmonary arterial pressure 〉30 mmHg), 6 of these patients had Down's syndrome. Hemodynamic measurements were taken in room air, 100% oxygen, 5 and 40 parts per million NO (NO5 and NO40) by inhalation. The differences between two observations within the same group were determined by the two-tailed paired t-test. A pulmonary vascular resistance (R p) regression curve was constructed by using linear regression analysis. The percentage change in pulmonary arterial pressure per systemic arterial pressure (P p/P s) with NO40 (P p/P s-40) exceeded that of P p/P s-5 (p 〈 0.0001). The percentage change for the R p with NO40 (Rp-40) was larger than that for the R p-5 (p= 0.0003). The percentage change of P p/P s-5 and that with oxygen were similar (p= 0.266). The relationship between R p-5 and R p-40 was linear. In conclusion, the effects of NO5 were equivalent to 100% oxygen but less than NO40. NO5 should initially be used to test pulmonary reactivity. If there is no response, patients should still be given NO40.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002469900463
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