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  • Key words: Protein evolution — Trypsin — Tandem gene duplication — Fourier transform — Repeated segment  (1)
  • localized sigma co-ordinates  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular evolution 47 (1998), S. 353-362 
    ISSN: 1432-1432
    Keywords: Key words: Protein evolution — Trypsin — Tandem gene duplication — Fourier transform — Repeated segment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. The trypsin family of serine proteases is one of the most studied protein families, with a wealth of amino acid sequence information available in public databases. Since trypsin-like enzymes are widely distributed in living organisms in nature, likely evolutionary scenarios have been proposed. A novel methodology for Fourier transformation of biological sequences (FOTOBIS) is presented. The methodology is well suited for the identification of the size and extent of short repeats in protein sequences. In the present paper the trypsin family of enzymes is analyzed with FOTOBIS and strong evidence for tandem gene duplication is found. A likely evolutionary path for the development of present-day trypsins involved an intrinsic extensive tandem gene duplication of a small DNA fragment of 15–18 nucleotides, corresponding to five or six amino acids. This ancestral trypsin gene was subsequently duplicated, leading to the earliest version of a full-sized trypsin, from which the contemporary trypsins have developed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 22 (1996), S. 815-834 
    ISSN: 0271-2091
    Keywords: vertical discretization ; sigma co-ordinates ; localized sigma co-ordinates ; tidal flow ; numerical experimentation ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: We propose an empirical law for vertical nodal placement in tidal simulations that depends on a single parameter p. The influence of dimensionless numbers on the optimal value of pis analysed through a series of numerical experiments for an individual vertical and a single value of pis found to be adequate for all cases. The proposed law can lead to gains in accuracy of over two orders of magnitude relative to a uniform grid and compares favourably with non-uniform grids previously used in the literature. In practical applications the most effective use of this law may require each vertical to have a different number of nodes. Criteria for the distribution of the total number of nodes among different verticals are also proposed, based on the concept of equalizing errors across the domain. The usefulness of the overall approach is demonstrated through a two-dimensional laterally averaged application to a synthetic estuary.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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