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  • Cervus elaphus  (1)
  • Gameto cides  (1)
  • Key words: SLE — Cytokines — B-cells — Autoantibodies  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 48 (1999), S. 255-261 
    ISSN: 1420-908X
    Keywords: Key words: SLE — Cytokines — B-cells — Autoantibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Systemic lupus erythematosus (SLE) is an autoimmune disease most prevalent in women between the ages of twenty and sixty. Successful treatment remains challenging due to a lack of understanding of the underlying mechanisms and multiple symptoms ranging from skin rashes to glomerulonephritis. The pathogenesis of SLE has been linked to a B-cell hyperproliferation unique to afflicted patients. These B-cells generate large quantities of IgG autoantibodies, ultimately capable of leading to lupus nephritis and renal failure. The significance of cytokines in SLE and in murine lupus, a related disease in mice, has been debated, particularly with respect to B-cell activity. Potential roles of auto-regulatory and inflammatory cytokines have been investigated. In particular, IL-6 and IL-10 have been shown to be key factors in regulating autoantibody-secreting B-cell activity in lupus. Here, we will provide a critical overview of our current knowledge of the regulatory roles of these two cytokines in SLE.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Sexual plant reproduction 4 (1991), S. 235-243 
    ISSN: 1432-2145
    Keywords: Male sterility ; Pollen ; Anther ; Gameto cides ; Chemical hybridizing agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Several unrelated compounds are known to selectively inhibit the development of the male gametophyte. When applied at suitable dosages to plants at the appropriate stages of anther development, these substances block the formation of fertile pollen. The affected stage of pollen development is characteristic of the specific chemical structure of the compound, ranging from effects on microspore meiosis to the formation of pollen defective in the ability to germinate or fertilize. The range of effects mediated by these substances, and by known male-sterile mutants, indicates that microspore development has several critical phases that are particularly sensitive to fatal inhibition. We propose that chemical inhibitors of pollen development deserve attention as tools for elucidating the regulation of pollen development.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Comparative clinical pathology 4 (1994), S. 76-85 
    ISSN: 1433-2981
    Keywords: Cervus elaphus ; Haptoglobin ; Plasma viscosity ; Reference values ; Seasonal variation ; Sedation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An automatic haematology analyser (Technicon H6000/C) providing red cell, white cell and platelet parameters was calibrated for the blood of red deer Cervus elaphus. Haematology reference values for these parameters, plasma viscosity and plasma fibrinogen are presented for defined groups of female weaner red deer (n = 123), adult red deer hinds (n = 86) and weaner male red deer (n = 37), the latter being bled using physical restraint and also using xylazine sedation. Age, sex, sedation and season-related differences were found. Reference values are also presented for serum haptoglobin in adult hinds and levels were similar to those seen in cattle. Seasonal analysis of the hinds was checked on a further group of 336 hinds, showing higher acute phase proteins in spring and summer which were possibly related to an increase in eosinophil count starting in spring and continuing through into autumn, and slightly increased neutrophil counts in the summer. Circulating red cell mass parameters were higher in the winter in the hinds, whereas the reverse was found in male weaner deer. There was some evidence of mild iron deficiency in late pregnancy and during lactation in the females. MCV appeared to increase with age, and basophil count was higher in the male deer than in females. No evidence for a neutrophil leucocytosis during pregnancy was found. Plasma viscosity was essentially the same for adult hinds and male weaners, but slightly lower in female weaners, the male group showing a slightly higher upper limit for fibrinogen. Plasma viscosity exhibited seasonal variation.
    Type of Medium: Electronic Resource
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